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The aged lymphoid tissue environment fails to support naïve T cell homeostasis.

  • Becklund BR Department of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, 92037, USA.
  • Purton JF Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA, 92037, USA.
  • Ramsey C Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA, 92037, USA.
  • Favre S Department of Biochemistry, Center for Immunity and Infection, University of Lausanne, 1066 Epalinges, Switzerland.
  • Vogt TK Department of Biochemistry, Center for Immunity and Infection, University of Lausanne, 1066 Epalinges, Switzerland.
  • Martin CE Department of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, 92037, USA.
  • Spasova DS Department of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, 92037, USA.
  • Sarkisyan G Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA, 92037, USA.
  • LeRoy E Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA, 92037, USA.
  • Tan JT Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA, 92037, USA.
  • Wahlus H Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA, 92037, USA.
  • Bondi-Boyd B Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA, 92037, USA.
  • Luther SA Department of Biochemistry, Center for Immunity and Infection, University of Lausanne, 1066 Epalinges, Switzerland.
  • Surh CD Department of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, 92037, USA.
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  • 2016-08-03
Published in:
  • Scientific reports. - 2016
Animals
Cell Proliferation
Homeostasis
Immunologic Memory
Lymphocyte Activation
Lymphoid Tissue
Mice
Mice, Inbred C57BL
T-Lymphocyte Subsets
English Aging is associated with a gradual loss of naïve T cells and a reciprocal increase in the proportion of memory T cells. While reduced thymic output is important, age-dependent changes in factors supporting naïve T cells homeostasis may also be involved. Indeed, we noted a dramatic decrease in the ability of aged mice to support survival and homeostatic proliferation of naïve T cells. The defect was not due to a reduction in IL-7 expression, but from a combination of changes in the secondary lymphoid environment that impaired naïve T cell entry and access to key survival factors. We observed an age-related shift in the expression of homing chemokines and structural deterioration of the stromal network in T cell zones. Treatment with IL-7/mAb complexes can restore naïve T cell homeostatic proliferation in aged mice. Our data suggests that homeostatic mechanisms that support the naïve T cell pool deteriorate with age.
Language
  • English
Open access status
gold
Identifiers
Persistent URL
https://sonar.ch/global/documents/181582
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