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X-rays can trigger the FLASH effect: Ultra-high dose-rate synchrotron light source prevents normal brain injury after whole brain irradiation in mice.
Journal article

X-rays can trigger the FLASH effect: Ultra-high dose-rate synchrotron light source prevents normal brain injury after whole brain irradiation in mice.

  • Montay-Gruel P Department of Radiation Oncology/DO/Radio-Oncology/CHUV, Lausanne University Hospital, Switzerland.
  • Bouchet A Rayonnement synchrotron et Recherche médicale, Université Grenoble Alpes, 38000 Grenoble, France.
  • Jaccard M Institute of Radiation Physics (IRA), Lausanne University Hospital, Switzerland.
  • Patin D Institute of Radiation Physics (IRA), Lausanne University Hospital, Switzerland.
  • Serduc R Rayonnement synchrotron et Recherche médicale, Université Grenoble Alpes, 38000 Grenoble, France. Electronic address: serduc@esrf.fr.
  • Aim W Rayonnement synchrotron et Recherche médicale, Université Grenoble Alpes, 38000 Grenoble, France.
  • Petersson K Department of Radiation Oncology/DO/Radio-Oncology/CHUV, Lausanne University Hospital, Switzerland; Institute of Radiation Physics (IRA), Lausanne University Hospital, Switzerland.
  • Petit B Department of Radiation Oncology/DO/Radio-Oncology/CHUV, Lausanne University Hospital, Switzerland.
  • Bailat C Institute of Radiation Physics (IRA), Lausanne University Hospital, Switzerland.
  • Bourhis J Department of Radiation Oncology/DO/Radio-Oncology/CHUV, Lausanne University Hospital, Switzerland.
  • Bräuer-Krisch E ESRF, European Synchrotron Radiation Facility, Grenoble, France.
  • Vozenin MC Department of Radiation Oncology/DO/Radio-Oncology/CHUV, Lausanne University Hospital, Switzerland. Electronic address: marie-catherine.vozenin@chuv.ch.
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  • 2018-09-05
Published in:
  • Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. - 2018
Cognitive impairment
Radiation-induced brain injury
Synchrotron radiation
Ultra-high dose-rate X-ray radiation
Animals
Brain Injuries
Cranial Irradiation
Female
Hippocampus
Memory
Mice
Mice, Inbred C57BL
Radiation Injuries, Experimental
Synchrotrons
X-Rays
English This study is the first proof of concept that the FLASH effect can be triggered by X-rays. Our results show that a 10 Gy whole-brain irradiation delivered at ultra-high dose-rate with synchrotron generated X-rays does not induce memory deficit; it reduces hippocampal cell-division impairment and induces less reactive astrogliosis.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/181871
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