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Innate lymphoid cells in antitumor immunity.
Journal article

Innate lymphoid cells in antitumor immunity.

  • Salomé B Translational Tumor Immunology Group, Department of Fundamental Oncology, University of Lausanne, Epalinges, Switzerland.
  • Jandus C Translational Tumor Immunology Group, Department of Fundamental Oncology, University of Lausanne, Epalinges, Switzerland.
  • 2018-01-19
Published in:
  • Journal of leukocyte biology. - 2018
Innate
cancer
cell subsets
cytokines
Animals
Humans
Immunity, Innate
Inflammation
Lymphocytes
Neoplasms
English Innate lymphoid cells (ILCs) are the most recently characterized subset of innate lymphocytes. Based on their specific transcriptional regulation, cytokine secretion pattern and effector functions ILCs mirror the different CD4 T helper cell subsets, with the unique attributes of acting locally in early phases of immune responses, in an antigen-independent manner. In this review, we discuss how ILCs have been implicated in tumorigenesis. Their presence might favor or inhibit tumor growth, depending on the cytokines released and the specific tumor microenvironment. As our understanding of ILCs' contribution to antitumor responses advances, clinical options to target ILCs in antitumor therapies are also emerging.
Language
  • English
Identifiers
Persistent URL
https://sonar.ch/global/documents/182115
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