Immunomodulatory Effects of Aerobic Training in Obesity
- Nickel, Thomas Medizinische Klinik und Poliklinik I, Campus Grosshadern, Ludwig-Maximilians-Universität München, Marchioninistr.15, 81377 Munich, Germany
- Hanssen, Henner Department of Prevention and Sports Medicine, Technische Universität München, Klinikum rechts der Isar (MRI), 80809 Munich, Germany
- Emslander, Ingrid Department of Prevention and Sports Medicine, Technische Universität München, Klinikum rechts der Isar (MRI), 80809 Munich, Germany
- Drexel, Verena Department of Prevention and Sports Medicine, Technische Universität München, Klinikum rechts der Isar (MRI), 80809 Munich, Germany
- Hertel, Gernot Department of Prevention and Sports Medicine, Technische Universität München, Klinikum rechts der Isar (MRI), 80809 Munich, Germany
- Schmidt-Trucksäss, Arno Sports Medicine, Institute of Exercise and Health Sciences, University Basel, 4003 Basel, Switzerland
- Summo, Claudia Medizinische Klinik und Poliklinik I, Campus Grosshadern, Ludwig-Maximilians-Universität München, Marchioninistr.15, 81377 Munich, Germany
- Sisic, Zeljka Medizinische Klinik und Poliklinik I, Campus Grosshadern, Ludwig-Maximilians-Universität München, Marchioninistr.15, 81377 Munich, Germany
- Lambert, Marius Medizinische Klinik und Poliklinik I, Campus Grosshadern, Ludwig-Maximilians-Universität München, Marchioninistr.15, 81377 Munich, Germany
- Hoster, Eva Institute for Medical Informatics Biometry and Epidemiology, Ludwig-Maximilians-Universität München, 81377 Munich, Germany
- Halle, Martin Department of Prevention and Sports Medicine, Technische Universität München, Klinikum rechts der Isar (MRI), 80809 Munich, Germany
- Weis, Michael Medizinische Klinik und Poliklinik I, Campus Grosshadern, Ludwig-Maximilians-Universität München, Marchioninistr.15, 81377 Munich, Germany
Published in:
- Mediators of Inflammation. - Hindawi Limited. - 2011, vol. 2011, p. 1-10
English
Introduction . Physical inactivity and obesity are independent risk factors for atherosclerosis. We analyzed the immunomodulatory capacity of 10-week intensified exercise training (ET) in obese and lean athletes. Markers of the innate immune response were investigated in obese (ONE: ET≤40 km/week) and lean athletes (LNE: ET≤40 km/week and LE: ET≥55 km/week).Methods . Circulating dendritic cells (DC) were analyzed by flow-cytometry for BDCA-1/-2-expression. TLR-2/-4/-7 and MyD88 were analyzed by RT-PCR and Western blot. Circulating oxLDL levels were analyzed by ELISA.Results . BDCA-1 expression at baseline was lower in ONE compared to both other groups (ONE 0.15%; LNE 0.27%; LE 0.33%; ), but significantly increased in ONE after training (+50%; ). In contrast, BDCA-2 expression at baseline was higher in ONE (ONE 0.25%; LNE 0.11%; LE 0.09%; ) and decreased in ONE after the 10-week training period (−27%; ). Gene activations of TLR-4 and TLR-7 with corresponding protein increase were found for all three groups (/) compared to pre training. A reduction of oxLDL levels was seen in ONE (−61%; ).Conclusions . Intensified exercise induces an increase of BDCA-1+ DCs and TLR-4/-7 in obese athletes. We hereby describe new immune modulatory effects, which—through regular aerobic exercise—modulate innate immunity and pro-inflammatory cytokines in obesity.
- Language
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- English
- Open access status
- gold
- Identifiers
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- DOI 10.1155/2011/308965
- ISSN 0962-9351
- Persistent URL
- https://sonar.ch/global/documents/183560
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