Journal article
An artificial metalloenzyme for olefin metathesis.
- Mayer C Laboratory of Organic Chemistry, ETH Zürich, 8093 Zürich, Switzerland.
- Gillingham DG
- Ward TR
- Hilvert D
- 2011-10-13
Published in:
- Chemical communications (Cambridge, England). - 2011
Allyl Compounds
Archaeal Proteins
Catalysis
Heat-Shock Proteins
Metalloproteins
Methanococcales
Ruthenium
Sulfonamides
Toluene
English
A Grubbs-Hoveyda type olefin metathesis catalyst, equipped with an electrophilic bromoacetamide group, was used to modify a cysteine-containing variant of a small heat shock protein from Methanocaldococcus jannaschii. The resulting artificial metalloenzyme was found to be active under acidic conditions in a benchmark ring closing metathesis reaction.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1039/c1cc15005g
- PMID 21991583
- Persistent URL
- https://sonar.ch/global/documents/183870
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