Journal article
MIB-1 (Ki-67) immunostaining of breast cancer cells in cytologic smears.
- Dalquen P Institute for Pathology, University of Basel, Switzerland.
- Baschiera B
- Chaffard R
- Dieterich H
- Feichter GE
- Krmer K
- Torhorst J
- 1997-03-01
Published in:
- Acta cytologica. - 1997
Biopsy, Needle
Breast Neoplasms
Carcinoma, Ductal, Breast
Carcinoma, Lobular
Female
Humans
Immunohistochemistry
Ki-67 Antigen
Reproducibility of Results
English
OBJECTIVE
The reliability of immunocytochemical evaluation of proliferation activity was tested using the monoclonal antibody MIB-1 on cytologic specimens.
STUDY DESIGN
The study comprised 83 frozen tissue smears (FTSs) and 51 fine needle aspirates (FNAs) from 119 breast cancer patients. MIB-1 labeling indexes (LIs) were compared with various tumor parameters assessed on histologic material.
RESULTS
MIB-1 LIs established on cytologic smears were significantly different in ductal and lobular carcinomas (P = .024) and correlated significantly with mitotic activity (P < .0001), histologic grade (P < .0001) and S-phase fraction (P < .0001). Essentially the same results were obtained on FTSs and FNAs.
CONCLUSION
Proliferative activity can reliably be evaluated by FNA cytology, and the evaluation of MIB-1 LIs may complement cytologic grading of breast cancer. The evaluation of proliferation activity may, therefore, contribute to the selection of candidates for adjuvant chemotherapy.
The reliability of immunocytochemical evaluation of proliferation activity was tested using the monoclonal antibody MIB-1 on cytologic specimens.
STUDY DESIGN
The study comprised 83 frozen tissue smears (FTSs) and 51 fine needle aspirates (FNAs) from 119 breast cancer patients. MIB-1 labeling indexes (LIs) were compared with various tumor parameters assessed on histologic material.
RESULTS
MIB-1 LIs established on cytologic smears were significantly different in ductal and lobular carcinomas (P = .024) and correlated significantly with mitotic activity (P < .0001), histologic grade (P < .0001) and S-phase fraction (P < .0001). Essentially the same results were obtained on FTSs and FNAs.
CONCLUSION
Proliferative activity can reliably be evaluated by FNA cytology, and the evaluation of MIB-1 LIs may complement cytologic grading of breast cancer. The evaluation of proliferation activity may, therefore, contribute to the selection of candidates for adjuvant chemotherapy.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1159/000332448
- PMID 9100748
- Persistent URL
- https://sonar.ch/global/documents/184239
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