Experimental evolution of parasites.
- Ebert D Universität Basel, Zoologisches Institut, Rheinsprung 9, 4051 Basel, Switzerland. ebert@ubaclu.unibas.ch
- 1998-11-20
Published in:
- Science (New York, N.Y.). - 1998
Adaptation, Physiological
Animals
Bacteria
Biological Evolution
Fungi
Genetic Variation
Host-Parasite Interactions
Mutation
Parasites
Serial Passage
Virulence
Viruses
English
Serial passage experiments are a form of experimental evolution that is frequently used in applied sciences; for example, in vaccine development. During these experiments, molecular and phenotypic evolution can be monitored in real time, providing insights into the causes and consequences of parasite evolution. Within-host competition generally drives an increase in a parasite's virulence in a new host, whereas the parasite becomes avirulent to its former host, indicating a trade-off between parasite fitnesses on different hosts. Understanding why parasite virulence seldom escalates similarly in natural populations could help us to manage virulence and deal with emerging diseases.
- Language
-
- English
- Open access status
- green
- Identifiers
-
- DOI 10.1126/science.282.5393.1432
- PMID 9822369
- Persistent URL
- https://sonar.ch/global/documents/184282
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