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Metabolic Effects of Glucose-Fructose Co-Ingestion Compared to Glucose Alone during Exercise in Type 1 Diabetes.

  • Bally L Department of Diabetes, Endocrinology, Clinical Nutrition and Metabolism, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland. lia.bally@insel.ch.
  • Kempf P Department of Diabetes, Endocrinology, Clinical Nutrition and Metabolism, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland. patrick.kempf@insel.ch.
  • Zueger T Department of Diabetes, Endocrinology, Clinical Nutrition and Metabolism, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland. t.zueger@bluewin.ch.
  • Speck C Department of Diabetes, Endocrinology, Clinical Nutrition and Metabolism, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland. christian.speck@outlook.com.
  • Pasi N Department of Diabetes, Endocrinology, Clinical Nutrition and Metabolism, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland. nicola.pasi@students.unibe.ch.
  • Ciller C Department of Radiology, University Hospital Centre and University of Lausanne, 1011 Lausanne, Switzerland. ciller@gmail.com.
  • Feller K Department of Diabetes, Endocrinology, Clinical Nutrition and Metabolism, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland. katrin.feller2@insel.ch.
  • Loher H Department of Diabetes, Endocrinology, Clinical Nutrition and Metabolism, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland. hannah.loher@bluewin.ch.
  • Rosset R Department of Physiology, Faculty of Biology and Medicine, University of Lausanne, 1005 Lausanne, Switzerland. robin.Rosset@unil.ch.
  • Wilhelm M Department of Cardiology, Interdisciplinary Center for Sports Medicine, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland. matthias.wilhelm@insel.ch.
  • Boesch C Department of Clinical Research and Department of Radiology, University of Bern, 3010 Bern, Switzerland. chris.boesch@insel.ch.
  • Buehler T Department of Clinical Research and Department of Radiology, University of Bern, 3010 Bern, Switzerland. buehler_tania@gmx.net.
  • Dokumaci AS Department of Clinical Research and Department of Radiology, University of Bern, 3010 Bern, Switzerland. ayse.dokumaci@insel.ch.
  • Tappy L Department of Physiology, Faculty of Biology and Medicine, University of Lausanne, 1005 Lausanne, Switzerland. luc.tappy@unil.ch.
  • Stettler C Department of Diabetes, Endocrinology, Clinical Nutrition and Metabolism, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland. christoph.stettler@insel.ch.
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  • 2017-02-24
Published in:
  • Nutrients. - 2017
carbohydrates
exercise
fructose
glucose
glycaemia
substrate oxidation
type 1 diabetes
Adult
Bicycling
Blood Glucose
Diabetes Mellitus, Type 1
Diet
Dietary Carbohydrates
Dietary Fats
Eating
Exercise
Fructose
Glucose
Glycogen
Hormones
Humans
Insulin
Lactic Acid
Male
Muscles
Oxygen Consumption
Sports Nutritional Physiological Phenomena
Young Adult
English This paper aims to compare the metabolic effects of glucose-fructose co-ingestion (GLUFRU) with glucose alone (GLU) in exercising individuals with type 1 diabetes mellitus. Fifteen male individuals with type 1 diabetes (HbA1c 7.0% ± 0.6% (53 ± 7 mmol/mol)) underwent a 90 min iso-energetic continuous cycling session at 50% VO2max while ingesting combined glucose-fructose (GLUFRU) or glucose alone (GLU) to maintain stable glycaemia without insulin adjustment. GLUFRU and GLU were labelled with 13C-fructose and 13C-glucose, respectively. Metabolic assessments included measurements of hormones and metabolites, substrate oxidation, and stable isotopes. Exogenous carbohydrate requirements to maintain stable glycaemia were comparable between GLUFRU and GLU (p = 0.46). Fat oxidation was significantly higher (5.2 ± 0.2 vs. 2.6 ± 1.2 mg·kg-1·min-1, p < 0.001) and carbohydrate oxidation lower (18.1 ± 0.8 vs. 24.5 ± 0.8 mg·kg-1·min-1p < 0.001) in GLUFRU compared to GLU, with decreased muscle glycogen oxidation in GLUFRU (10.2 ± 0.9 vs. 17.5 ± 1.0 mg·kg-1·min-1, p < 0.001). Lactate levels were higher (2.2 ± 0.2 vs. 1.8 ± 0.1 mmol/L, p = 0.012) in GLUFRU, with comparable counter-regulatory hormones between GLUFRU and GLU (p > 0.05 for all). Glucose and insulin levels, and total glucose appearance and disappearance were comparable between interventions. Glucose-fructose co-ingestion may have a beneficial impact on fuel metabolism in exercising individuals with type 1 diabetes without insulin adjustment, by increasing fat oxidation whilst sparing glycogen.
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  • English
Open access status
gold
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https://sonar.ch/global/documents/185133
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