New insights on the role of paired membrane structures in coronavirus replication.
- V'kovski P Federal Institute of Virology and Immunology, Mittelhäusern, Bern, Switzerland; Graduate School for Biomedical Sciences, University of Bern, Switzerland.
- Al-Mulla H School of Biological Sciences, University of Reading, Reading, Berkshire, United Kingdom; University of Baghdad, College of Science, Baghdad, Iraq.
- Thiel V Federal Institute of Virology and Immunology, Mittelhäusern, Bern, Switzerland; Vetsuisse Faculty, University of Bern, Bern, Switzerland. Electronic address: Volker.thiel@vetsuisse.unibe.ch.
- Neuman BW School of Biological Sciences, University of Reading, Reading, Berkshire, United Kingdom. Electronic address: b.w.neuman@reading.ac.uk.
- 2015-01-01
Published in:
- Virus research. - 2015
Membrane rearrangement
RNA virus replication
Replicative organelle
Virus factory
Cell Membrane
Coronaviridae
Host-Pathogen Interactions
Virus Replication
English
The replication of coronaviruses, as in other positive-strand RNA viruses, is closely tied to the formation of membrane-bound replicative organelles inside infected cells. The proteins responsible for rearranging cellular membranes to form the organelles are conserved not just among the Coronaviridae family members, but across the order Nidovirales. Taken together, these observations suggest that the coronavirus replicative organelle plays an important role in viral replication, perhaps facilitating the production or protection of viral RNA. However, the exact nature of this role, and the specific contexts under which it is important have not been fully elucidated. Here, we collect and interpret the recent experimental evidence about the role and importance of membrane-bound organelles in coronavirus replication.
- Language
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- English
- Open access status
- green
- Identifiers
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- DOI 10.1016/j.virusres.2014.12.021
- PMID 25550072
- Persistent URL
- https://sonar.ch/global/documents/185165
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