Journal article
An antimicrobial bicyclic peptide from chemical space against multidrug resistant Gram-negative bacteria.
- Di Bonaventura I Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, 3012 Bern, Switzerland. jean-louis.reymond@dcb.unibe.ch.
- Baeriswyl S
- Capecchi A
- Gan BH
- Jin X
- Siriwardena TN
- He R
- Köhler T
- Pompilio A
- Di Bonaventura G
- van Delden C
- Javor S
- Reymond JL
- 2018-05-03
Published in:
- Chemical communications (Cambridge, England). - 2018
Acinetobacter baumannii
Anti-Bacterial Agents
Antimicrobial Cationic Peptides
Bacillus subtilis
Biofilms
Cell Membrane
Drug Evaluation, Preclinical
Drug Resistance, Multiple, Bacterial
Humans
Microbial Sensitivity Tests
Molecular Dynamics Simulation
Peptides, Cyclic
Protein Structure, Secondary
Pseudomonas aeruginosa
Small Molecule Libraries
English
We used the concept of chemical space to explore a virtual library of bicyclic peptides formed by double thioether cyclization of a precursor linear peptide, and identified an antimicrobial bicyclic peptide (AMBP) with remarkable activity against several MDR strains of Acinetobacter baumannii and Pseudomonas aeruginosa.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1039/c8cc02412j
- PMID 29717727
- Persistent URL
- https://sonar.ch/global/documents/185166
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