Back
The midbrain periaqueductal gray as an integrative and interoceptive neural structure for breathing.
Journal article

The midbrain periaqueductal gray as an integrative and interoceptive neural structure for breathing.

  • Faull OK Translational Neuromodeling Unit, University of Zürich and ETH Zürich, Zürich, Switzerland; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK. Electronic address: faull@biomed.ee.ethz.ch.
  • Subramanian HH Boston Scientific, Valencia, USA.
  • Ezra M Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
  • Pattinson KTS Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
  • 2019-01-07
Published in:
  • Neuroscience and biobehavioral reviews. - 2019
Breathlessness
Interoception
Periaqueductal gray
Respiration
Animals
Brain
Brain Mapping
Humans
Nerve Net
Periaqueductal Gray
Pulmonary Disease, Chronic Obstructive
Respiration
English The periaqueductal gray (PAG) plays a critical role in autonomic function and behavioural responses to threatening stimuli. Recent evidence has revealed the PAG's potential involvement in the perception of breathlessness, a highly threatening respiratory symptom. In this review, we outline the current evidence in animals and humans on the role of the PAG in respiratory control and in the perception of breathlessness. While recent work has unveiled dissociable brain activity within the lateral PAG during perception of breathlessness and ventrolateral PAG during conditioned anticipation in healthy humans, this is yet to be translated into diseases dominated by breathlessness symptomology, such as chronic obstructive pulmonary disease. Understanding how the sub-structures of the PAG differentially interact with interoceptive brain networks involved in the perception of breathlessness will help towards understanding discordant symptomology, and may reveal treatment targets for those debilitated by chronic and pervasive breathlessness.
Language
  • English
Open access status
hybrid
Identifiers
Persistent URL
https://sonar.ch/global/documents/185258
Statistics
Document views: 56 File downloads: