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Common Functions of Disordered Proteins across Evolutionary Distant Organisms.

  • Wallmann A Medical Research Council Toxicology Unit, University of Cambridge, Cambridge CB2 1QR, UK.
  • Kesten C Department of Biology, ETH Zurich, 8092 Zurich, Switzerland.
  • 2020-03-25
Published in:
  • International journal of molecular sciences. - 2020
functional comparison
intrinsically disordered proteins
plants
protein function
English Intrinsically disordered proteins and regions typically lack a well-defined structure and thus fall outside the scope of the classic sequence-structure-function relationship. Hence, classic sequence- or structure-based bioinformatic approaches are often not well suited to identify homology or predict the function of unknown intrinsically disordered proteins. Here, we give selected examples of intrinsic disorder in plant proteins and present how protein function is shared, altered or distinct in evolutionary distant organisms. Furthermore, we explore how examining the specific role of disorder across different phyla can provide a better understanding of the common features that protein disorder contributes to the respective biological mechanism.
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  • English
Open access status
gold
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https://sonar.ch/global/documents/185299
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