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Current gaps in sepsis immunology: new opportunities for translational research.

  • Rubio I Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany; Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany.
  • Osuchowski MF Ludwig Boltzmann Institute for Experimental and Clinical Traumatology in the Austrian Workers' Compensation Board Research Center, Vienna, Austria.
  • Shankar-Hari M Guy's and St Thomas' NHS Foundation Trust, Intensive Care Unit support Offices, St Thomas' Hospital, UK; School of Immunology and Microbial Sciences, Kings College London, London, UK; Intensive Care National Audit and Research Centre, London, UK.
  • Skirecki T Laboratory of Flow Cytometry, Centre of Medical Postgraduate Education, Warsaw Poland.
  • Winkler MS Department of Anaesthesiology, University of Göttingen Medical Center, Georg-August University of Göttingen, Göttingen, Germany.
  • Lachmann G Department of Anesthesiology and Operative Intensive Care Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany; Berlin Institute of Health, Berlin, Germany.
  • La Rosée P Department of Internal Medicine, Schwarzwald-Baar Clinic, Villingen-Schwenningen, Germany.
  • Monneret G Immunology Laboratory, Hospices Civils de Lyon, Edouard Herriot Hospital, Lyon, France; Pathophysiology of Injury-induced Immunosuppression, Equipes d'Accueil 7426, Université Claude Bernard Lyon 1 - BioMerieux, Hospices Civils de Lyon, Edouard Herriot Hospital, Lyon, France.
  • Venet F Immunology Laboratory, Hospices Civils de Lyon, Edouard Herriot Hospital, Lyon, France; Pathophysiology of Injury-induced Immunosuppression, Equipes d'Accueil 7426, Université Claude Bernard Lyon 1 - BioMerieux, Hospices Civils de Lyon, Edouard Herriot Hospital, Lyon, France.
  • Bauer M Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany; Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany.
  • Brunkhorst FM Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany; Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany; Center for Clinical Studies, Jena University Hospital, Jena, Germany.
  • Kox M Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, Netherlands; Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands.
  • Cavaillon JM Experimental Neuropathology Unit, Institut Pasteur, Paris, France.
  • Uhle F Department of Anesthesiology, Heidelberg University Hospital, Heidelberg, Germany.
  • Weigand MA Department of Anesthesiology, Heidelberg University Hospital, Heidelberg, Germany.
  • Flohé SB Department of Trauma Surgery, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
  • Wiersinga WJ Division of Infectious Diseases and Center of Experimental and Molecular Medicine, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.
  • Martin-Fernandez M Hospital Universitario Río Hortega, Valladolid, Spain; Group for Biomedical Research in Sepsis, Instituto de Investigación Biomédica de Salamanca, Salamanca, Spain.
  • Almansa R Hospital Universitario Río Hortega, Valladolid, Spain; Group for Biomedical Research in Sepsis, Instituto de Investigación Biomédica de Salamanca, Salamanca, Spain; Centro de Investigación Biomedica En Red-Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain.
  • Martin-Loeches I Multidisciplinary Intensive Care Research Organization, St James's Hospital, Dublin, Ireland.
  • Torres A Centro de Investigación Biomedica En Red-Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain; Pneumology Department, Respiratory Institute, Hospital Clinic of Barcelona - Institut d'Investigacions Biomèdiques August Pi i Sunyer - University of Barcelona, Barcelona, Spain.
  • Giamarellos-Bourboulis EJ 4th Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
  • Girardis M Department of Anesthesia and Intensive Care, University of Modena and Reggio Emilia, Modena, Italy.
  • Cossarizza A Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia, Modena, Italy.
  • Netea MG Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands; Human Genomics Laboratory, Craiova University of Medicine and Pharmacy, Craiova, Romania; Department for Immunology and Metabolism, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany.
  • van der Poll T Division of Infectious Diseases and Center of Experimental and Molecular Medicine, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.
  • Scherag A Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany; Institute of Medical Statistics, Computer Science and Data Science, Jena University Hospital, Jena, Germany.
  • Meisel C Institute for Medical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany; Department of Immunology, Labor Berlin - Charité Vivantes, Berlin, Germany.
  • Schefold JC Department of Intensive Care Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
  • Bermejo-Martín JF Hospital Universitario Río Hortega, Valladolid, Spain; Group for Biomedical Research in Sepsis, Instituto de Investigación Biomédica de Salamanca, Salamanca, Spain; Centro de Investigación Biomedica En Red-Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain. Electronic address: jfbermejo@saludcastillayleon.es.
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  • 2019-10-22
Published in:
  • The Lancet. Infectious diseases. - 2019
Adaptive Immunity
Animals
Biomarkers
Disease Management
Disease Susceptibility
Host-Pathogen Interactions
Humans
Immune System
Immunity, Innate
Precision Medicine
Risk Factors
Sepsis
Translational Medical Research
English Increasing evidence supports a central role of the immune system in sepsis, but the current view of how sepsis affects immunity, and vice versa, is still rudimentary. The European Group on Immunology of Sepsis has identified major gaps that should be addressed with high priority, such as understanding how immunological alterations predispose to sepsis, key aspects of the immunopathological events during sepsis, and the long-term consequences of sepsis on patient's immunity. We discuss major unmet topics in those three categories, including the role of key immune cells, the cause of lymphopenia, organ-specific immunology, the dynamics of sepsis-associated immunological alterations, the role of the microbiome, the standardisation of immunological tests, the development of better animal models, and the opportunities offered by immunotherapy. Addressing these gaps should help us to better understand sepsis physiopathology, offering translational opportunities to improve its prevention, diagnosis, and care.
Language
  • English
Open access status
green
Identifiers
Persistent URL
https://sonar.ch/global/documents/185351
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