The initiation of post-synaptic protrusions.
- Hotulainen P Neuroscience Center, University of Helsinki, Helsinki, Finland; Minerva Foundation Institute for Medical Research, Helsinki, Finland.
- Saarikangas J Institute of Biochemistry , ETH Zurich, Switzerland.
- 2016-08-05
Published in:
- Communicative & integrative biology. - 2016
English
The post-synaptic spines of neuronal dendrites are highly elaborate membrane protrusions. Their anatomy, stability and density are intimately linked to cognitive performance. The morphological transitions of spines are powered by coordinated polymerization of actin filaments against the plasma membrane, but how the membrane-associated polymerization is spatially and temporally regulated has remained ill defined. Here, we discuss our recent findings showing that dendritic spines can be initiated by direct membrane bending by the I-BAR protein MIM/Mtss1. This lipid phosphatidylinositol (PI(4,5)P2) signaling-activated membrane bending coordinated spatial actin assembly and promoted spine formation. From recent advances, we formulate a general model to discuss how spatially concentrated protein-lipid microdomains formed by multivalent interactions between lipids and actin/membrane regulatory proteins might launch cell protrusions.
- Language
-
- English
- Open access status
- gold
- Identifiers
-
- DOI 10.1080/19420889.2015.1125053
- PMID 27489575
- Persistent URL
- https://sonar.ch/global/documents/185457
Statistics
Document views: 40
File downloads:
- Full-text: 0