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The phosphoinositide turnover of vascular smooth muscle cells is influenced by fish oil.
Journal article

The phosphoinositide turnover of vascular smooth muscle cells is influenced by fish oil.

  • 1988-12-01
Published in:
  • Journal of hypertension. Supplement : official journal of the International Society of Hypertension. - 1988
Animals
Cells, Cultured
Eicosapentaenoic Acid
Fish Oils
In Vitro Techniques
Inositol Phosphates
Muscle, Smooth, Vascular
Phosphatidylinositols
Rats
Thromboxane A2
English As the phosphoinositide cycle and high serum levels of low-density lipoprotein cholesterol may be involved in the pathogenesis of both hypertension and atherosclerosis, the effect of fish oil on low-density lipoprotein stimulation of phosphoinositide metabolism was studied in cultured rat vascular smooth muscle cells. Low-density lipoprotein-stimulated synthesis of inositol trisphosphate decreased to 5-48% of control values in vascular smooth muscle cells treated for 4 weeks with either fish oil or n-3 eicosapentaenoic acid (EPA), the active ingredient of fish oil. In addition, low-density lipoprotein-induced biosynthesis of thromboxane A2 was reduced by 50% in vascular smooth muscle cells precultured with either fish oil or EPA. Thus, our results may explain the mechanisms by which fish oil exerts its beneficial effects on both atherosclerosis and hypertension.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/185470
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