The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research.

Percie du Sert N; Hurst V; Ahluwalia A; Alam S; Avey MT; Baker M; Browne WJ; Clark A; Cuthill IC; Dirnagl U; Emerson M; Garner P; Holgate ST; Howells DW; Karp NA; Lazic SE; Lidster K; MacCallum CJ; Macleod M; Pearl EJ; Petersen OH; Rawle F; Reynolds P; Rooney K; Sena ES; Silberberg SD; Steckler T; Würbel H

doi:10.1371/journal.pbio.3000410

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The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research.

Percie du Sert N NC3Rs, London, United Kingdom.
Hurst V NC3Rs, London, United Kingdom.
Ahluwalia A The William Harvey Research Institute, London, United Kingdom.
Alam S Taylor & Francis Group, London, United Kingdom.
Avey MT Health Science Practice, ICF, Durham, North Carolina, United States of America.
Baker M Nature, San Francisco, California, United States of America.
Browne WJ School of Education, University of Bristol, Bristol, United Kingdom.
Clark A PLOS ONE, Cambridge, United Kingdom.
Cuthill IC School of Biological Sciences, University of Bristol, Bristol, United Kingdom.
Dirnagl U QUEST Center for Transforming Biomedical Research, Berlin Institute of Health & Department of Experimental Neurology, Charite Universitätsmedizin Berlin, Berlin, Germany.
Emerson M National Heart and Lung Institute, Imperial College London, London, United Kingdom.
Garner P Centre for Evidence Synthesis in Global Health, Clinical Sciences Department, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
Holgate ST Clinical and Experimental Sciences, University of Southampton, Southampton, United Kingdom.
Howells DW Tasmanian School of Medicine, University of Tasmania, Hobart, Australia.
Karp NA Data Sciences & Quantitative Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge, United Kingdom.
Lazic SE Prioris.ai Inc, Ottawa, Canada.
Lidster K NC3Rs, London, United Kingdom.
MacCallum CJ Hindawi Ltd, London, United Kingdom.
Macleod M Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.
Pearl EJ NC3Rs, London, United Kingdom.
Petersen OH Academia Europaea Knowledge Hub, Cardiff University, Cardiff, United Kingdom.
Rawle F Medical Research Council, London, United Kingdom.
Reynolds P Statistics in Anesthesiology Research (STAR) Core, Department of Anesthesiology, College of Medicine, University of Florida, Gainesville, Florida, United States of America.
Rooney K Discipline of Exercise and Sport Science, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.
Sena ES Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.
Silberberg SD National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, United States of America.
Steckler T Janssen Pharmaceutica NV, Beerse, Belgium.
Würbel H Veterinary Public Health Institute, Vetsuisse Faculty, University of Bern, Bern, Switzerland.

2020-07-15

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PLoS biology. - 2020

English Reproducible science requires transparent reporting. The ARRIVE guidelines (Animal Research: Reporting of In Vivo Experiments) were originally developed in 2010 to improve the reporting of animal research. They consist of a checklist of information to include in publications describing in vivo experiments to enable others to scrutinise the work adequately, evaluate its methodological rigour, and reproduce the methods and results. Despite considerable levels of endorsement by funders and journals over the years, adherence to the guidelines has been inconsistent, and the anticipated improvements in the quality of reporting in animal research publications have not been achieved. Here, we introduce ARRIVE 2.0. The guidelines have been updated and information reorganised to facilitate their use in practice. We used a Delphi exercise to prioritise and divide the items of the guidelines into 2 sets, the "ARRIVE Essential 10," which constitutes the minimum requirement, and the "Recommended Set," which describes the research context. This division facilitates improved reporting of animal research by supporting a stepwise approach to implementation. This helps journal editors and reviewers verify that the most important items are being reported in manuscripts. We have also developed the accompanying Explanation and Elaboration (E&E) document, which serves (1) to explain the rationale behind each item in the guidelines, (2) to clarify key concepts, and (3) to provide illustrative examples. We aim, through these changes, to help ensure that researchers, reviewers, and journal editors are better equipped to improve the rigour and transparency of the scientific process and thus reproducibility.

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