Journal article
Inhibition of food intake in rats by the K+ channel opener cromakalim.
- Del Prete E Institut für Veterinär-Physiologie, Universität Zürich, Switzerland.
- Lutz TA
- Scharrer E
- 1996-04-01
Published in:
- Pharmacology, biochemistry, and behavior. - 1996
Animals
Benzopyrans
Cromakalim
Depression, Chemical
Diet
Eating
Gastric Emptying
Male
Potassium Channels
Pyrroles
Rats
Rats, Inbred Strains
Taste
Vagotomy
English
We studied the effect of the K+ channel opener cromakalim, which exhibits antihypertensive properties, on food intake in rats. Intraperitoneally injected cromakalim induced a dose-dependent (0.1, 0.5, and 1.0 mg/kg body wt.) reduction in food intake, which was associated with an inhibition of gastric emptying. The anorectic effect was not influenced by subdiaphragmatic vagotomy. Cromakalim's anorectic effect did not appear to be due to a learned taste aversion. Therefore, an intact abdominal vagus is not a prerequisite for cromakalim's anorectic effect.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1016/0091-3057(95)02090-x
- PMID 8801586
- Persistent URL
- https://sonar.ch/global/documents/185592
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