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Bioaccumulation of musk xylene (MX) in developing and adult rats of both sexes.
Journal article

Bioaccumulation of musk xylene (MX) in developing and adult rats of both sexes.

  • 1998-09-24
Published in:
  • Chemosphere. - 1998
Adipose Tissue
Animal Feed
Animals
Animals, Newborn
Chromatography, Gas
Female
Lactation
Male
Maternal-Fetal Exchange
Milk
Pregnancy
Rats
Sex Factors
Tissue Distribution
Water Pollutants, Chemical
Xylenes
English Bioaccumulation of musk xylene (MX) was measured by GC-ECD in adult and developing Long Evans rats. Males and females were fed with MX-containing chow (0.001, 0.01, 0.033, 0.1 g MX/kg food pellets) for 10 weeks before mating. Treatment continued during pregnancy and lactation. Offspring exhibited dose-dependent MX accumulation with 1/2-3/4 of adult female or 3-4 times adult male body fat levels (at 0.1 mg/kg food) at days 1 and 14. Milk levels were comparable to adult female adipose tissue. Data indicate significant transplacental passage and exposure via maternal milk. In rats fed with MX in adulthood, levels were highest in adipose tissue with significant amounts in other organs (ovary, adrenal). Female tissue levels were 3.7-6.8 times higher. This unexplained sex difference was unrelated to lipid content and was absent in offspring.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/185694
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