Serotonin-2 receptors and human sleep: effect of a selective antagonist on EEG power spectra.
- Landolt HP Institute of Pharmacology, University of Zürich, Switzerland.
- Meier V
- Burgess HJ
- Finelli LA
- Cattelin F
- Achermann P
- Borbély AA
- 1999-08-24
Published in:
- Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. - 1999
Adult
Body Temperature
Electroencephalography
Fluorobenzenes
Heart Rate
Humans
Male
Phenols
Receptors, Serotonin
Serotonin Antagonists
Sleep
Sleep Stages
English
To investigate the effect on the sleep EEG, a 1-mg oral dose of SR 46349B, a novel 5-HT2 antagonist, was administered three hours before bedtime. The drug enhanced slow wave sleep (SWS) and reduced stage 2 without affecting subjective sleep quality. In nonREM sleep (NREMS) EEG slow-wave activity (SWA; power within 0.75-4.5 Hz) was increased and spindle frequency activity (SFA; power within 12.25-15 Hz) was decreased. The relative NREMS power spectrum showed a bimodal pattern with the main peak at 1.5 Hz and a secondary peak at 6 Hz. A regional analysis based on bipolar derivations along the antero-posterior axis revealed significant 'treatment' x 'derivation' interactions within the 9-16 Hz range. In enhancing SWA and attenuating SFA, the 5-HT2 receptor antagonist mimicked the effect of sleep deprivation, whereas the pattern of the NREMS spectrum differed.
- Language
-
- English
- Open access status
- bronze
- Identifiers
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- DOI 10.1016/S0893-133X(99)00052-4
- PMID 10457543
- Persistent URL
- https://sonar.ch/global/documents/185743
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