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A Hippocampal Model for Behavioral Time Acquisition and Fast Bidirectional Replay of Spatio-Temporal Memory Sequences.

  • Matheus Gauy M Department of Computer Science, Institute of Theoretical Computer Science, ETH Zurich, Zurich, Switzerland.
  • Lengler J Department of Computer Science, Institute of Theoretical Computer Science, ETH Zurich, Zurich, Switzerland.
  • Einarsson H Department of Computer Science, Institute of Theoretical Computer Science, ETH Zurich, Zurich, Switzerland.
  • Meier F Department of Computer Science, Institute of Theoretical Computer Science, ETH Zurich, Zurich, Switzerland.
  • Weissenberger F Department of Computer Science, Institute of Theoretical Computer Science, ETH Zurich, Zurich, Switzerland.
  • Yanik MF Department of Information Technology and Electrical Engineering, Institute for Neuroinformatics, ETH Zurich, Zurich, Switzerland.
  • Steger A Department of Computer Science, Institute of Theoretical Computer Science, ETH Zurich, Zurich, Switzerland.
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  • 2019-01-09
Published in:
  • Frontiers in neuroscience. - 2018
cholinergic modulation
dendritic spikes
disinhibition
hippocampal replays
one-shot learning
place cells
reverse replays
synfire chains
English The hippocampus is known to play a crucial role in the formation of long-term memory. For this, fast replays of previously experienced activities during sleep or after reward experiences are believed to be crucial. But how such replays are generated is still completely unclear. In this paper we propose a possible mechanism for this: we present a model that can store experienced trajectories on a behavioral timescale after a single run, and can subsequently bidirectionally replay such trajectories, thereby omitting any specifics of the previous behavior like speed, etc, but allowing repetitions of events, even with different subsequent events. Our solution builds on well-known concepts, one-shot learning and synfire chains, enhancing them by additional mechanisms using global inhibition and disinhibition. For replays our approach relies on dendritic spikes and cholinergic modulation, as supported by experimental data. We also hypothesize a functional role of disinhibition as a pacemaker during behavioral time.
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  • English
Open access status
gold
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https://sonar.ch/global/documents/185761
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