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CcpA Affects Infectivity of Staphylococcus aureus in a Hyperglycemic Environment.

  • Bischoff M Institute for Medical Microbiology and Hygiene, Saarland UniversityHomburg, Germany.
  • Wonnenberg B Institute of Anatomy and Cell Biology, Saarland UniversityHomburg, Germany.
  • Nippe N Institute of Immunology, University of MunsterMunster, Germany.
  • Nyffenegger-Jann NJ Division of Infection Biology, Department of Biomedicine, University Hospital BaselBasel, Switzerland.
  • Voss M Department of Internal Medicine V - Pulmonology, Allergology and Critical Care Medicine, Saarland University HospitalHomburg, Germany.
  • Beisswenger C Department of Internal Medicine V - Pulmonology, Allergology and Critical Care Medicine, Saarland University HospitalHomburg, Germany.
  • Sunderkötter C Department of Dermatology, University of MunsterMunster, Germany.
  • Molle V DIMNP, CNRS, Univ MontpellierMontpellier, France.
  • Dinh QT Department of Experimental Pneumology and Allergology, Saarland University HospitalHomburg, Germany.
  • Lammert F Department of Medicine II, Saarland University HospitalHomburg, Germany.
  • Bals R Department of Internal Medicine V - Pulmonology, Allergology and Critical Care Medicine, Saarland University HospitalHomburg, Germany.
  • Herrmann M Institute for Medical Microbiology and Hygiene, Saarland UniversityHomburg, Germany.
  • Somerville GA School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-LincolnLincoln, NE, USA.
  • Tschernig T Institute of Anatomy and Cell Biology, Saarland UniversityHomburg, Germany.
  • Gaupp R Institute for Medical Microbiology and Hygiene, Saarland UniversityHomburg, Germany.
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  • 2017-05-25
Published in:
  • Frontiers in cellular and infection microbiology. - 2017
CcpA
Staphylococcus aureus
carbon catabolic regulation
hyperglycemia
infectivity
Animals
Bacterial Proteins
Blood Glucose
Carbon
Cytokines
Female
Gene Deletion
Gene Expression Regulation, Bacterial
Hemolysis
Lung
Mice
Mice, Inbred C57BL
Mice, Inbred NOD
Mice, Obese
Repressor Proteins
Staphylococcal Infections
Staphylococcal Protein A
Staphylococcus aureus
Virulence Factors
English Many bacteria regulate the expression of virulence factors via carbon catabolite responsive elements. In Gram-positive bacteria, the predominant mediator of carbon catabolite repression is the catabolite control protein A (CcpA). Hyperglycemia is a widespread disorder that predisposes individuals to an array of symptoms and an increased risk of infections. In hyperglycemic individuals, the bacterium Staphylococcus aureus causes serious, life-threatening infections. The importance of CcpA in regulating carbon catabolite repression in S. aureus suggests it may be important for infections in hyperglycemic individuals. To test this suggestion, hyperglycemic non-obese diabetic (NOD; blood glucose level ≥20 mM) mice were challenged with the mouse pathogenic S. aureus strain Newman and the isogenic ccpA deletion mutant (MST14), and the effects on infectivity were determined. Diabetic NOD mice challenged with the ccpA deletion mutant enhanced the symptoms of infection in an acute murine pneumonia model relative to the parental strain. Interestingly, when diabetic NOD mice were used in footpad or catheter infection models, infectivity of the ccpA mutant decreased relative to the parental strain. These differences greatly diminished when normoglycemic NOD mice (blood glucose level ≤ 10 mM) were used. These data suggest that CcpA is important for infectivity of S. aureus in hyperglycemic individuals.
Language
  • English
Open access status
gold
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https://sonar.ch/global/documents/185893
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