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Symbiont-induced odorant binding proteins mediate insect host hematopoiesis
Journal article

Symbiont-induced odorant binding proteins mediate insect host hematopoiesis

  • Benoit, Joshua B Department of Biological Sciences, University of Cincinnati, Cincinnati, United States
  • Vigneron, Aurélien Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, United States
  • Broderick, Nichole A ORCID Institute for Systems Genomics, University of Connecticut, Storrs, United States
  • Wu, Yineng Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, United States
  • Sun, Jennifer S ORCID Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, United States
  • Carlson, John R ORCID Interdepartmental Neuroscience Program, Yale University, New Haven, United States
  • Aksoy, Serap ORCID Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, United States
  • Weiss, Brian L ORCID Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, United States
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  • 2017-1-12
Published in:
  • eLife. - eLife Sciences Publications, Ltd. - 2017, vol. 6
English Symbiotic bacteria assist in maintaining homeostasis of the animal immune system. However, the molecular mechanisms that underlie symbiont-mediated host immunity are largely unknown. Tsetse flies (Glossina spp.) house maternally transmitted symbionts that regulate the development and function of their host’s immune system. Herein we demonstrate that the obligate mutualist, Wigglesworthia, up-regulates expression of odorant binding protein six in the gut of intrauterine tsetse larvae. This process is necessary and sufficient to induce systemic expression of the hematopoietic RUNX transcription factor lozenge and the subsequent production of crystal cells, which actuate the melanotic immune response in adult tsetse. Larval Drosophila’s indigenous microbiota, which is acquired from the environment, regulates an orthologous hematopoietic pathway in their host. These findings provide insight into the molecular mechanisms that underlie enteric symbiont-stimulated systemic immune system development, and indicate that these processes are evolutionarily conserved despite the divergent nature of host-symbiont interactions in these model systems.
Language
  • English
Open access status
gold
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Persistent URL
https://sonar.ch/global/documents/186098
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