Back
Full-text
Journal article

The human microbiota is associated with cardiometabolic risk across the epidemiologic transition.

  • Fei N Microbiome Center, Department of Surgery, University of Chicago, Chicago, IL, United States of America.
  • Bernabé BP Microbiome Center, Department of Surgery, University of Chicago, Chicago, IL, United States of America.
  • Lie L Public Health Sciences, Stritch School of Medicine, Loyola University Chicago, Maywood, IL, United States of America.
  • Baghdan D Public Health Sciences, Stritch School of Medicine, Loyola University Chicago, Maywood, IL, United States of America.
  • Bedu-Addo K Department of Physiology, SMS, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
  • Plange-Rhule J Department of Physiology, SMS, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
  • Forrester TE Solutions for Developing Countries, University of the West Indies, Mona, Kingston, Jamaica.
  • Lambert EV Research Unit for Exercise Science and Sports Medicine, University of Cape Town, Cape Town, South Africa.
  • Bovet P Institute of Social & Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland.
  • Gottel N Microbiome Center, Department of Surgery, University of Chicago, Chicago, IL, United States of America.
  • Riesen W Center for Laboratory Medicine, Canton Hospital, St. Gallen, Switzerland.
  • Korte W Center for Laboratory Medicine, Canton Hospital, St. Gallen, Switzerland.
  • Luke A Public Health Sciences, Stritch School of Medicine, Loyola University Chicago, Maywood, IL, United States of America.
  • Kliethermes SA Department of Orthopedics and Rehabilitation, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America.
  • Layden BT Division of Endocrinology, Diabetes, and Metabolism, University of Illinois at Chicago, Chicago, IL, United States of America.
  • Gilbert JA Microbiome Center, Department of Surgery, University of Chicago, Chicago, IL, United States of America.
  • Dugas LR Public Health Sciences, Stritch School of Medicine, Loyola University Chicago, Maywood, IL, United States of America.
Show more…
  • 2019-07-25
Published in:
  • PloS one. - 2019
Adult
Cardiovascular Diseases
Female
Gastrointestinal Microbiome
Ghana
Humans
Jamaica
Male
Metabolic Diseases
Middle Aged
Mouth
Risk Factors
South Africa
United States
Waist Circumference
English Oral and fecal microbial biomarkers have previously been associated with cardiometabolic (CM) risk, however, no comprehensive attempt has been made to explore this association in minority populations or across different geographic regions. We characterized gut- and oral-associated microbiota and CM risk in 655 participants of African-origin, aged 25-45, from Ghana, South Africa, Jamaica, and the United States (US). CM risk was classified using the CM risk cut-points for elevated waist circumference, elevated blood pressure and elevated fasted blood glucose, low high-density lipoprotein (HDL), and elevated triglycerides. Gut-associated bacterial alpha diversity negatively correlated with elevated blood pressure and elevated fasted blood glucose. Similarly, gut bacterial beta diversity was also significantly differentiated by waist circumference, blood pressure, triglyceridemia and HDL-cholesterolemia. Notably, differences in inter- and intra-personal gut microbial diversity were geographic-region specific. Participants meeting the cut-points for 3 out of the 5 CM risk factors were significantly more enriched with Lachnospiraceae, and were significantly depleted of Clostridiaceae, Peptostreptococcaceae, and Prevotella. The predicted relative proportions of the genes involved in the pathways for lipopolysaccharides (LPS) and butyrate synthesis were also significantly differentiated by the CM risk phenotype, whereby genes involved in the butyrate synthesis via lysine, glutarate and 4-aminobutyrate/succinate pathways and LPS synthesis pathway were enriched in participants with greater CM risk. Furthermore, inter-individual oral microbiota diversity was also significantly associated with the CM risk factors, and oral-associated Streptococcus, Prevotella, and Veillonella were enriched in participants with 3 out of the 5 CM risk factors. We demonstrate that in a diverse cohort of African-origin adults, CM risk is significantly associated with reduced microbial diversity, and the enrichment of specific bacterial taxa and predicted functional traits in both gut and oral environments. As well as providing new insights into the associations between the gut and oral microbiota and CM risk, this study also highlights the potential for novel therapeutic discoveries which target the oral and gut microbiota in CM risk.
Language
  • English
Open access status
gold
Identifiers
Persistent URL
https://sonar.ch/global/documents/186149
Statistics
Document views: 18 File downloads:
  • Full-text: 0