Journal article
Low penetrance of antibiotics in the epithelial lining fluid. The role of inhaled antibiotics in patients with bronchiectasis.
- Karampitsakos T 5th Department of Pneumonology, Hospital for Thoracic Diseases, "Sotiria", Athens, Greece.
- Papaioannou O 5th Department of Pneumonology, Hospital for Thoracic Diseases, "Sotiria", Athens, Greece.
- Kaponi M 5th Department of Pneumonology, Hospital for Thoracic Diseases, "Sotiria", Athens, Greece.
- Kozanidou A Department of Internal Medicine, Hippokrateion Hospital, Thessaloniki, Greece.
- Hillas G 5th Department of Pneumonology, Hospital for Thoracic Diseases, "Sotiria", Athens, Greece.
- Stavropoulou E Service de Médecine Interne, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland.
- Bouros D First Academic Department of Pneumonology, Hospital for Thoracic Diseases, "Sotiria", Medical School, National and Kapodistrian University of Athens, Athens, Greece.
- Dimakou K 5th Department of Pneumonology, Hospital for Thoracic Diseases, "Sotiria", Athens, Greece. Electronic address: kdimakou@yahoo.com.
- 2020-01-01
Published in:
- Pulmonary pharmacology & therapeutics. - 2020
English
Plasma drug concentrations, spectrum of antibacterial activity and minimum inhibitory concentration (MIC) had been widely considered as markers of the efficacy of antibiotics. Nonetheless, in several cases, antibiotics characterized by all these features were ineffective for the treatment of respiratory tract infections. A typical paradigm represented the case of patients with bronchiectasis who do not always benefit from antibiotics and thus experiencing increased sputum production, worse quality of life, more rapid forced expiratory volume in the first second (FEV1) decline, more frequent exacerbations and increased mortality rates, especially those with Pseudomonas aeruginosa (P. aeruginosa) chronic infection. Subsequently, penetrance of antibiotics in the epithelial lining fluid has gradually emerged as another key factor for the outcome of antibiotic treatment. Given that a plethora of antibiotics presented with poor or intermediate penetrance in the epithelial lining fluid, inhaled antibiotics targeting directly the site of infection emerged as a new option for patients with respiratory disorders including patients with bronchiectasis. This review article intends to summarize the current state of knowledge for the penetrance of antibiotics in the epithelial lining fluid and present results from clinical trials of inhaled antibiotics in patients with bronchiectasis of etiology other than cystic fibrosis.
- Language
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- English
- Open access status
- closed
- Identifiers
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- DOI 10.1016/j.pupt.2019.101885
- PMID 31891761
- Persistent URL
- https://sonar.ch/global/documents/186202
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