Differential contributions of subthalamic beta rhythms and 1/f broadband activity to motor symptoms in Parkinson's disease.
- Martin S 1Defitech Chair in Brain-Machine Interface (CNBI), Center for Neuroprosthetics (CNP), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
- Iturrate I 1Defitech Chair in Brain-Machine Interface (CNBI), Center for Neuroprosthetics (CNP), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
- Chavarriaga R 1Defitech Chair in Brain-Machine Interface (CNBI), Center for Neuroprosthetics (CNP), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
- Leeb R 1Defitech Chair in Brain-Machine Interface (CNBI), Center for Neuroprosthetics (CNP), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
- Sobolewski A 1Defitech Chair in Brain-Machine Interface (CNBI), Center for Neuroprosthetics (CNP), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
- Li AM 1Defitech Chair in Brain-Machine Interface (CNBI), Center for Neuroprosthetics (CNP), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
- Zaldivar J 4Department of Clinical Neurosciences (Neurology and Neurosurgery), University Hospital of Vaud (CHUV), Lausanne, Switzerland.
- Peciu-Florianu I 4Department of Clinical Neurosciences (Neurology and Neurosurgery), University Hospital of Vaud (CHUV), Lausanne, Switzerland.
- Pralong E 4Department of Clinical Neurosciences (Neurology and Neurosurgery), University Hospital of Vaud (CHUV), Lausanne, Switzerland.
- Castro-Jiménez M 4Department of Clinical Neurosciences (Neurology and Neurosurgery), University Hospital of Vaud (CHUV), Lausanne, Switzerland.
- Benninger D 4Department of Clinical Neurosciences (Neurology and Neurosurgery), University Hospital of Vaud (CHUV), Lausanne, Switzerland.
- Vingerhoets F 4Department of Clinical Neurosciences (Neurology and Neurosurgery), University Hospital of Vaud (CHUV), Lausanne, Switzerland.
- Knight RT 2Helen Wills Neuroscience Institute, University of California, Berkeley, CA USA.
- Bloch J 4Department of Clinical Neurosciences (Neurology and Neurosurgery), University Hospital of Vaud (CHUV), Lausanne, Switzerland.
- Millán JDR 1Defitech Chair in Brain-Machine Interface (CNBI), Center for Neuroprosthetics (CNP), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
- 2018-11-13
Published in:
- NPJ Parkinson's disease. - 2018
English
Excessive beta oscillatory activity in the subthalamic nucleus (STN) is linked to Parkinson's Disease (PD) motor symptoms. However, previous works have been inconsistent regarding the functional role of beta activity in untreated Parkinsonian states, questioning such role. We hypothesized that this inconsistency is due to the influence of electrophysiological broadband activity -a neurophysiological indicator of synaptic excitation/inhibition ratio- that could confound measurements of beta activity in STN recordings. Here we propose a data-driven, automatic and individualized mathematical model that disentangles beta activity and 1/f broadband activity in the STN power spectrum, and investigate the link between these individual components and motor symptoms in thirteen Parkinsonian patients. We show, using both modeled and actual data, how beta oscillatory activity significantly correlates with motor symptoms (bradykinesia and rigidity) only when broadband activity is not considered in the biomarker estimations, providing solid evidence that oscillatory beta activity does correlate with motor symptoms in untreated PD states as well as the significant impact of broadband activity. These findings emphasize the importance of data-driven models and the identification of better biomarkers for characterizing symptom severity and closed-loop applications.
- Language
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- English
- Open access status
- gold
- Identifiers
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- DOI 10.1038/s41531-018-0068-y
- PMID 30417084
- Persistent URL
- https://sonar.ch/global/documents/186309
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