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Clinical Relevance and Characteristics of Aspergillus calidoustus and Other Aspergillus Species of Section Usti.

  • Glampedakis E Infectious Diseases Service, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland.
  • Erard V Clinique de Médecine et spécialités, Infectiologie, HFR-Fribourg, 1708 Fribourg, Switzerland.
  • Lamoth F Infectious Diseases Service, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland.
  • 2020-06-18
Published in:
  • Journal of fungi (Basel, Switzerland). - 2020
Aspergillus granulosus
Aspergillus insuetus
Aspergillus keveii
Aspergillus pseudodeflectus
Aspergillus puniceus
Aspergillus ustus
invasive aspergillosis
English The Aspergilli of section Usti (group ustus) are represented by over 20 species, of which Aspergillus calidoustus is the most relevant human pathogen. Invasive aspergillosis (IA) caused by these fungi is rare but could represent an emerging issue among the expanding population of patients with long-term immunosuppression receiving antifungal prophylaxis. Clinicians should be aware of this unusual type of IA, which often exhibits distinct clinical features, such as an insidious and prolonged course and a high occurrence of extra-pulmonary manifestations, such as skin/soft tissue or brain lesions. Moreover, these Aspergillus spp. pose a therapeutic challenge because of their decreased susceptibility to azole drugs. In this review, we outline the microbiological and clinical characteristics of IA due to Aspergillus spp. of section Usti and discuss the therapeutic options.
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  • English
Open access status
gold
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https://sonar.ch/global/documents/186401
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