Journal article
Criterion validity of ultrasound in the identification of calcium pyrophosphate crystal deposits at the knee: an OMERACT ultrasound study.
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Filippou G
Section of Rheumatology, Department of Medical Sciences, University of Ferrara, Ferrara, Italy gf.filippou@gmail.com.
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Scanu A
Department of Medicine-DIMED, Rheumatology Unit, University of Padova, Padova, Italy.
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Adinolfi A
Rheumatology Department, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy.
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Toscano C
Rheumatology Department, Azienda Ospedaliera Regionale San Carlo, Potenza, Italy.
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Gambera D
Orthopedics Department, Rugani Hospital, Monteriggioni, Italy.
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Largo R
Joint and Bone Research Unit, Rheumatology Department, IIS-Fundacion Jimenez Diaz, Madrid, Spain.
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Naredo E
Department of Rheumatology and Joint and Bone Research Unit, Hospital Universitario Fundacion Jimenez Diaz, Madrid, Spain.
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Calvo E
Department of Orthopaedic Surgery, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain.
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Herrero-Beaumont G
Department of Rheumatology and Joint and Bone Research Unit, Hospital Universitario Fundacion Jimenez Diaz, Madrid, Spain.
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Zufferey P
Rheumatology Department, University of Lausanne, CHUV, Lausanne, Switzerland.
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Bonjour CM
Rheumatology Department, University of Lausanne, CHUV, Lausanne, Switzerland.
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MacCarter DK
Rheumatology Department, North Valley Hospital, Whitefish, Montana, USA.
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Makman S
Rheumatology Department, North Valley Hospital, Whitefish, Montana, USA.
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Weber Z
Rheumatology Department, North Valley Hospital, Whitefish, Montana, USA.
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Figus F
Rheumatology Unit, Department of Clinical and Biological Sciences, Università degli Studi di Torino, Torino, Italy.
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Möller I
Rheumatology, Instituto Poal de Reumatologia, Barcelona, Spain.
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Gutierrez M
Rheumatology Department, Instituto Nacional de Rehabilitacion, Mexico, Mexico.
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Pineda C
Rheumatology Department, Instituto Nacional de Rehabilitacion, Mexico, Mexico.
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Clavijo Cornejo D
Rheumatology Department, Instituto Nacional de Rehabilitacion, Mexico, Mexico.
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Garcia H
Rheumatology Department, Instituto Nacional de Rehabilitacion, Mexico, Mexico.
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Ilizaliturri V
Rheumatology Department, Instituto Nacional de Rehabilitacion, Mexico, Mexico.
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Mendoza Torres J
Rheumatology Department, Instituto Nacional de Rehabilitacion, Mexico, Mexico.
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Pichardo R
Rheumatology Department, Instituto Nacional de Rehabilitacion, Mexico, Mexico.
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Rodriguez Delgado LC
Rheumatology Department, Instituto Nacional de Rehabilitacion, Mexico, Mexico.
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Filippucci E
Rheumatology Unit, Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona, Italy.
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Cipolletta E
Rheumatology Unit, Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona, Italy.
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Serban T
Rheumatology Department, Carol Davila University, Bucharest, Romania.
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Cirstoiu C
Rheumatology Department, Carol Davila University, Bucharest, Romania.
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Vreju FA
Rheumatology Department, University of Medicine and Pharmacy of Craiova, Craiova, Romania.
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Grecu D
Rheumatology Department, University of Medicine and Pharmacy of Craiova, Craiova, Romania.
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Mouterde G
Rheumatology, University of Montpellier, Montpellier, France.
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Govoni M
Section of Rheumatology, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.
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Punzi L
Department of Medicine, Ospedale SS Giovanni e Paolo Venezia, Venezia, Italy.
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Damjanov NS
Rheumatology, University of Belgrade School of Medicine, Belgrade, Serbia.
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Keen HI
Medicine and Pharmacology Department, The University of Western Australia, Murdoch, Perth, Australia.
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Bruyn GA
Department of Rheumatology, Reumakliniek Lelystad, Lelystad, The Netherlands.
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Terslev L
Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen University, Copenhagen, Denmark.
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D'Agostino MA
Infection et inflammation, Laboratory of Excellence INFLAMEX, Université Paris-Saclay, Montigny-Le-Bretonneux, France.
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Scirè CA
Section of Rheumatology, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.
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Iagnocco A
Rheumatology Unit, Department of Clinical and Biological Sciences, Università degli Studi di Torino, Torino, Italy.
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Published in:
- Annals of the rheumatic diseases. - 2020
English
OBJECTIVE
To evaluate the discriminatory ability of ultrasound in calcium pyrophosphate deposition disease (CPPD), using microscopic analysis of menisci and knee hyaline cartilage (HC) as reference standard.
METHODS
Consecutive patients scheduled for knee replacement surgery, due to osteoarthritis (OA), were enrolled. Each patient underwent ultrasound examination of the menisci and HC of the knee, scoring each site for presence/absence of CPPD. Ultrasound signs of inflammation (effusion, synovial proliferation and power Doppler) were assessed semiquantitatively (0-3). The menisci and condyles, retrieved during surgery, were examined microscopically by optical light microscopy and by compensated polarised microscopy. CPPs were scored as present/absent in six different samples from the surface and from the internal part of menisci and cartilage. Ultrasound and microscopic analysis were performed by different operators, blinded to each other's findings.
RESULTS
11 researchers from seven countries participated in the study. Of 101 enrolled patients, 68 were included in the analysis. In 38 patients, the surgical specimens were insufficient. The overall diagnostic accuracy of ultrasound for CPPD was of 75%-sensitivity of 91% (range 71%-87% in single sites) and specificity of 59% (range 68%-92%). The best sensitivity and specificity were obtained by assessing in combination by ultrasound the medial meniscus and the medial condyle HC (88% and 76%, respectively). No differences were found between patients with and without CPPD regarding ultrasound signs of inflammation.
CONCLUSION
Ultrasound demonstrated to be an accurate tool for discriminating CPPD. No differences were found between patents with OA alone and CPPD plus OA regarding inflammation.
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Language
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Open access status
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closed
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Identifiers
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Persistent URL
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https://sonar.ch/global/documents/186422
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