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Combining a Toggle Switch and a Repressilator within the AC-DC Circuit Generates Distinct Dynamical Behaviors.

  • Perez-Carrasco R Department of Mathematics, University College London, Gower Street, WC1E 6BT London, UK. Electronic address: r.carrasco@ucl.ac.uk.
  • Barnes CP Department of Cell and Developmental Biology, University College London, Gower Street, WC1E 6BT London, UK; Department of Genetics, Evolution and Environment, University College London, Gower Street, WC1E 6BT London, UK.
  • Schaerli Y Department of Fundamental Microbiology, University of Lausanne, Biophore Building, 1015 Lausanne, Switzerland.
  • Isalan M Department of Life Sciences, Imperial College London, SW7 2AZ London, UK.
  • Briscoe J The Francis Crick Institute, 1 Midland Road, NW1 1AT London, UK.
  • Page KM Department of Mathematics, University College London, Gower Street, WC1E 6BT London, UK.
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  • 2018-03-26
Published in:
  • Cell systems. - 2018
coherence
coherence resonance
dynamical systems
excitable systems
gene regulatory networks
multifunctional circuits
multistability
oscillations
synthetic biology
Gene Regulatory Networks
Models, Genetic
Models, Theoretical
Systems Theory
English Although the structure of a genetically encoded regulatory circuit is an important determinant of its function, the relationship between circuit topology and the dynamical behaviors it can exhibit is not well understood. Here, we explore the range of behaviors available to the AC-DC circuit. This circuit consists of three genes connected as a combination of a toggle switch and a repressilator. Using dynamical systems theory, we show that the AC-DC circuit exhibits both oscillations and bistability within the same region of parameter space; this generates emergent behaviors not available to either the toggle switch or the repressilator alone. The AC-DC circuit can switch on oscillations via two distinct mechanisms, one of which induces coherence into ensembles of oscillators. In addition, we show that in the presence of noise, the AC-DC circuit can behave as an excitable system capable of spatial signal propagation or coherence resonance. Together, these results demonstrate how combinations of simple motifs can exhibit multiple complex behaviors.
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  • English
Open access status
hybrid
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https://sonar.ch/global/documents/186654
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