Journal article
Analyses of thrombi in acute ischemic stroke: A consensus statement on current knowledge and future directions.
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De Meyer SF
1 Laboratory for Thrombosis Research, KU Leuven Campus Kulak Kortrijk, Kortrijk, Belgium.
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Andersson T
2 Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.
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Baxter B
5 Department of Radiology, Erlanger Hospital, University of Tennessee, Chattanooga.
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Bendszus M
6 Department of Neuroradiology, University of Heidelberg, Heidelberg, Germany.
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Brouwer P
3 Department of Neuroradiology, Karolinska University Hospital, Stockholm, Sweden.
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Brinjikji W
7 Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
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Campbell BC
8 Department of Medicine and Neurology, Melbourne Brain Centre at the Royal Melbourne Hospital, University of Melbourne, Grattan Street, Parkville, VIC 3050, Australia.
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Costalat V
9 Interventional and Diagnostic Neuroradiology, Montpellier University Hospital, Montpellier, France.
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Dávalos A
10 Acute Stroke Unit, Department of Neurosciences, Hospital Universitari Germans Trias i Pujol, Barcelona, Spain.
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Demchuk A
11 Department of Clinical Neurosciences and Radiology, Cumming School of Medicine, University of Calgary, Canada.
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Dippel D
12 Department of Neurology, Erasmus University Medical Center, Rotterdam, Netherlands.
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Fiehler J
13 Department of Neuroradiology, University Medical Center, Hamburg, Germany.
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Fischer U
14 Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
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Gilvarry M
15 Neuravi Thromboembolic Initiative, Neuravi Ltd, Galway, Ireland.
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Gounis MJ
16 Division of Neuroimaging and Intervention and New England Center for Stroke Research, Department of Radiology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
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Gralla J
17 Institute of Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
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Jansen O
18 Department of Radiology and Neuroradiology, UKSH, Kiel, Germany.
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Jovin T
19 Department of Neurology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
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Kallmes D
7 Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
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Khatri P
20 Department of Neurology, University of Cincinnati, Cincinnati, Ohio, USA.
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Lees KR
21 Institute of Cardiovascular and Medical Sciences, University of Glasgow, Scotland, UK.
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López-Cancio E
10 Acute Stroke Unit, Department of Neurosciences, Hospital Universitari Germans Trias i Pujol, Barcelona, Spain.
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Majoie C
22 Department of Radiology, Academic Medical Center, Amsterdam, the Netherlands.
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Marquering H
22 Department of Radiology, Academic Medical Center, Amsterdam, the Netherlands.
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Narata AP
24 Department of Neuroradiology, CHRU Hôpitaux de Tours, France.
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Nogueira R
25 Department of Neurology, Emory University, Atlanta, Georgia, USA.
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Ringleb P
26 Department of Neurology, University of Heidelberg, Heidelberg, Germany.
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Siddiqui A
27 Department of Neurosurgery, University of Buffalo, Buffalo, New York, USA.
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Szikora I
28 Department of Neuroradiology, National Institute of Neurosciences, Budapest, Hungary.
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Vale D
15 Neuravi Thromboembolic Initiative, Neuravi Ltd, Galway, Ireland.
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von Kummer R
29 Universitätsklinikum Carl Gustav Carus, Dresden, Germany.
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Yoo AJ
30 Texas Stroke Institute, Dallas, TX, USA.
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Hacke W
31 Department of Neurology, University Hospital Heidelberg, Ruprecht-Karls University, Heidelberg, Germany.
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Liebeskind DS
32 Neurovascular Imaging Research Core and UCLA Stroke Center, University of California, Los Angeles, California, USA.
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Published in:
- International journal of stroke : official journal of the International Stroke Society. - 2017
English
Limited data exist on clot composition and detailed characteristics of arterial thrombi associated with large vessel occlusion in acute ischemic stroke. Advances in endovascular thrombectomy and related imaging modalities have created a unique opportunity to analyze thrombi removed from cerebral arteries. Insights into thrombus composition, etiology, physical properties and neurovascular interactions may lead to future advancements in acute ischemic stroke treatment and improved clinical outcomes. Advances in imaging techniques may enhance clot characterization and inform therapeutic decision-making prior to treatment and reveal stroke etiology to guide secondary prevention. Current imaging techniques can provide some information about thrombi, but there remains much to evaluate about relationships that may exist among thrombus composition, occlusion characteristics and treatment outcomes. Improved pathophysiological characterization of clot types, their properties and how these properties change over time, together with clinical correlates from ongoing studies, may facilitate revascularization with thrombolysis and thrombectomy. Interdisciplinary approaches covering clinical, engineering and scientific aspects of thrombus research will be key to advancing the understanding of thrombi and improving acute ischemic stroke therapy. This consensus statement integrates recent research on clots and thrombi retrieved from cerebral arteries and provides a rationale for further analyses, including current opportunities and limitations.
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Language
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Open access status
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closed
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Persistent URL
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https://sonar.ch/global/documents/186816
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