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Detection of aristolochic acid in Chinese phytomedicines and dietary supplements used as slimming regimens.
Journal article

Detection of aristolochic acid in Chinese phytomedicines and dietary supplements used as slimming regimens.

  • 2002-11-28
Published in:
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. - 2003
Anti-Obesity Agents
Aristolochia
Aristolochic Acids
Carcinogens
Chromatography, High Pressure Liquid
Chromatography, Thin Layer
Dietary Supplements
Drugs, Chinese Herbal
Gas Chromatography-Mass Spectrometry
Humans
English Over the last 10 years, numerous cases of intoxications, leading for the most part to end-stage renal failure, have been reported after consumption of slimming regimens made of Chinese herbal preparations. These intoxications were associated with species of the Aristolochia genus, such as Aristolochia fangchi (Aristolochiaceae), known to contain very nephrotoxic and carcinogenic metabolites named aristolochic acids. Several commercial dietary supplements, teas and phytomedicines used as slimming regimens were analysed for their aristolochic acid I content. A preliminary detection of this toxic compound was made by thin-layer chromatography. The presence of aristolochic acid I in these preparations was confirmed by a HPLC/UV-DAD/MS analysis. A quantitative determination of aristolochic acid I was also achieved in the incriminated preparations using both UV and MS detection. Out of 42 analysed preparations, four were found to contain aristolochic acid I and two were suspected to contain aristolochic acid derivatives. Immediate removal of these products from the Swiss market was called for.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/189476
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