Journal article
The mobile order solubility equation applied to polyfunctional molecules: The non-hydroxysteroids in aqueous and non aqueous solvents.
- Ruelle P Institut d'Analyse Pharmaceutique, Section de Pharmacie, Université de Lausanne, BEP, CH-1015, Lausanne, Switzerland
- Farina-Cuendet A
- Kesselring UW
- 1999-09-09
Published in:
- International journal of pharmaceutics. - 1997
English
The solubility equation for real solutions derived from the thermodynamics of mobile order in liquids is used to predict the solubility of non-hydroxysteroids in water and in common polar and nonpolar organic solvents. Strictly obtained on a thermodynamic basis, the model allows not only correct predictions of the solubilities from the knowledge of a limited number of characteristics of solutes and solvents, but also enables a better understanding of the solution process and of the factors that determine solubility. Some practical rules are derived which might help to orient the choice of a solvent for liquid pharmaceutical forms.
- Language
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- English
- Open access status
- closed
- Identifiers
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- DOI 10.1016/s0378-5173(97)00240-8
- PMID 10477819
- Persistent URL
- https://sonar.ch/global/documents/189479
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