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Neonatal serotonin depletion affects developing and mature mouse cortical neurons.
Journal article

Neonatal serotonin depletion affects developing and mature mouse cortical neurons.

  • Durig J Institut de Biologie Cellulaire et de Morphologie, University of Lausanne, Switzerland.
  • Hornung JP
  • 2000-04-11
Published in:
  • Neuroreport. - 2000
5,7-Dihydroxytryptamine
Adrenergic Agents
Age Factors
Animals
Animals, Newborn
Calcium-Binding Proteins
Catecholamines
Cerebral Cortex
Dendrites
Mice
Mice, Inbred ICR
Neurons
Oxidopamine
Receptors, GABA-A
Serotonin
Serotonin Agents
Somatosensory Cortex
English The early expression of neurotransmitters and receptors in the developing brain has brought attention to their potential contribution in modulating neuronal developmental processes. Monoamines are among the first neurotransmitter systems to develop during embryogenesis. Depletion of neocortical serotonin or catecholamine afferents with selective neurotoxins resulted in a permanent alteration of the dendritic arborization of calretinin-containing interneurons, and a transient delay of parvalbumin and calbindin expression in a number of cortical neurones during the second postnatal week. The expression pattern of other developmentally regulated proteins, such as two subunits of the GABA(A) receptor, was not altered. Depletion of serotonin, and in part catecholamines, appeared to perturb several developmental processes of the cerebral cortex which would interfere with both its maturation and adult circuitry.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/189506
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