Journal article
Modelling structures in cryo-EM maps.
- Malhotra S Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck College, University of London, Malet Street, London WC1E 7HX, United Kingdom.
- Träger S Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne 1015, Switzerland.
- Dal Peraro M Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne 1015, Switzerland.
- Topf M Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck College, University of London, Malet Street, London WC1E 7HX, United Kingdom. Electronic address: m.topf@cryst.bbk.ac.uk.
- 2019-08-09
Published in:
- Current opinion in structural biology. - 2019
English
Recent advances in structure determination of sub-cellular structures using cryo-electron microscopy and tomography have enabled us to understand their architecture in a more detailed manner and gain insight into their function. The choice of approach to use for atomic model building, fitting, refinement and validation in the 3D map resulting from these experiments depends primarily on the resolution of the map and the prior information on the corresponding model. Here, we survey some of such methods and approaches and highlight their uses in specific recent examples.
- Language
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- English
- Open access status
- closed
- Identifiers
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- DOI 10.1016/j.sbi.2019.05.024
- PMID 31394387
- Persistent URL
- https://sonar.ch/global/documents/190471
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