Animal Models in Microbeam Radiation Therapy: A Scoping Review.
- Fernandez-Palomo C Institute of Anatomy, University of Bern, 3012 Bern, Switzerland.
- Fazzari J Institute of Anatomy, University of Bern, 3012 Bern, Switzerland.
- Trappetti V Institute of Anatomy, University of Bern, 3012 Bern, Switzerland.
- Smyth L Department of Obstetrics & Gynaecology, University of Melbourne, Parkville 3057, Australia.
- Janka H Medical Library, University Library Bern, University of Bern, 3012 Bern, Switzerland.
- Laissue J Institute of Anatomy, University of Bern, 3012 Bern, Switzerland.
- Djonov V Institute of Anatomy, University of Bern, 3012 Bern, Switzerland.
- 2020-02-29
Published in:
- Cancers. - 2020
animal models
microbeam radiation therapy
mouse
oncology
radiotherapy
rat
scoping review
spatial fractionation
synchrotron
English
BACKGROUND
Microbeam Radiation Therapy (MRT) is an innovative approach in radiation oncology where a collimator subdivides the homogeneous radiation field into an array of co-planar, high-dose beams which are tens of micrometres wide and separated by a few hundred micrometres.
OBJECTIVE
This scoping review was conducted to map the available evidence and provide a comprehensive overview of the similarities, differences, and outcomes of all experiments that have employed animal models in MRT.
METHODS
We considered articles that employed animal models for the purpose of studying the effects of MRT. We searched in seven databases for published and unpublished literature. Two independent reviewers screened citations for inclusion. Data extraction was done by three reviewers.
RESULTS
After screening 5688 citations and 159 full-text papers, 95 articles were included, of which 72 were experimental articles. Here we present the animal models and pre-clinical radiation parameters employed in the existing MRT literature according to their use in cancer treatment, non-neoplastic diseases, or normal tissue studies.
CONCLUSIONS
The study of MRT is concentrated in brain-related diseases performed mostly in rat models. An appropriate comparison between MRT and conventional radiotherapy (instead of synchrotron broad beam) is needed. Recommendations are provided for future studies involving MRT.
Microbeam Radiation Therapy (MRT) is an innovative approach in radiation oncology where a collimator subdivides the homogeneous radiation field into an array of co-planar, high-dose beams which are tens of micrometres wide and separated by a few hundred micrometres.
OBJECTIVE
This scoping review was conducted to map the available evidence and provide a comprehensive overview of the similarities, differences, and outcomes of all experiments that have employed animal models in MRT.
METHODS
We considered articles that employed animal models for the purpose of studying the effects of MRT. We searched in seven databases for published and unpublished literature. Two independent reviewers screened citations for inclusion. Data extraction was done by three reviewers.
RESULTS
After screening 5688 citations and 159 full-text papers, 95 articles were included, of which 72 were experimental articles. Here we present the animal models and pre-clinical radiation parameters employed in the existing MRT literature according to their use in cancer treatment, non-neoplastic diseases, or normal tissue studies.
CONCLUSIONS
The study of MRT is concentrated in brain-related diseases performed mostly in rat models. An appropriate comparison between MRT and conventional radiotherapy (instead of synchrotron broad beam) is needed. Recommendations are provided for future studies involving MRT.
- Language
-
- English
- Open access status
- gold
- Identifiers
-
- DOI 10.3390/cancers12030527
- PMID 32106397
- Persistent URL
- https://sonar.ch/global/documents/190779
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