Journal article
Amino acid sequence of the Felis catus prion protein.
- Lysek DA Institut für Molekularbiologie und Biophysik, HPK G5, Eidgenössische Technische Hochschule Zürich, Honggerberg, Zürich CH-8093, Switzerland. lysek@mol.biol.ethz.ch
- Nivon LG
- Wüthrich K
- 2004-10-12
Published in:
- Gene. - 2004
Amino Acid Sequence
Animals
Base Sequence
Cats
DNA
Molecular Sequence Data
Prions
Sequence Alignment
Sequence Analysis, DNA
Sequence Homology, Amino Acid
Sequence Homology, Nucleic Acid
English
A new determination of the house cat (Felis catus) prion protein gene sequence (fPrnp), which has so far been subject of controversy, is reported. The newly determined fPrnp sequence is similar to dog (Canis familiaris) and mink (Mustela putorius) Prnp, but differs significantly from both fPrnp sequences that were previously deposited in the GenBank. Comparison of the canine and feline prion protein sequences suggests a set of amino acid replacements relative to bovine PrP that might relate to the observed different susceptibilities of the two species to TSE infection by ingestion of BSE-infected beef.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1016/j.gene.2004.07.002
- PMID 15474307
- Persistent URL
- https://sonar.ch/global/documents/190982
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