Functional amyloids as natural storage of peptide hormones in pituitary secretory granules.
- Maji SK Laboratory of Physical Chemistry, Eidgenössische Technische Hochschule (ETH) Zürich, Wolfgang-Paulistrasse 10, CH-8093 Zürich, Switzerland.
- Perrin MH
- Sawaya MR
- Jessberger S
- Vadodaria K
- Rissman RA
- Singru PS
- Nilsson KP
- Simon R
- Schubert D
- Eisenberg D
- Rivier J
- Sawchenko P
- Vale W
- Riek R
- 2009-06-23
Published in:
- Science (New York, N.Y.). - 2009
Adrenocorticotropic Hormone
Amyloid
Animals
Cell Survival
Corticotropin-Releasing Hormone
Heparin, Low-Molecular-Weight
Humans
Hydrogen-Ion Concentration
Mice
Neurons
Peptide Hormones
Pituitary Gland
Pituitary Gland, Anterior
Pituitary Gland, Posterior
Pituitary Hormones
Protein Conformation
Rats
Secretory Vesicles
Sheep
Urocortins
beta-Endorphin
English
Amyloids are highly organized cross-beta-sheet-rich protein or peptide aggregates that are associated with pathological conditions including Alzheimer's disease and type II diabetes. However, amyloids may also have a normal biological function, as demonstrated by fungal prions, which are involved in prion replication, and the amyloid protein Pmel17, which is involved in mammalian skin pigmentation. We found that peptide and protein hormones in secretory granules of the endocrine system are stored in an amyloid-like cross-beta-sheet-rich conformation. Thus, functional amyloids in the pituitary and other organs can contribute to normal cell and tissue physiology.
- Language
-
- English
- Open access status
- green
- Identifiers
-
- DOI 10.1126/science.1173155
- PMID 19541956
- Persistent URL
- https://sonar.ch/global/documents/191212
Statistics
Document views: 49
File downloads:
- Full-text: 0