Journal article
Spinal MRI supporting myelopathic origin of early symptoms in unsuspected cobalamin deficiency.
- Fritschi J Department of Neurology, University of Bern, Bern, Switzerland. juerg.fritschi@insel.ch
- Sturzenegger M
- 2003-03-21
Published in:
- European neurology. - 2003
Adult
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Nerve Degeneration
Sensation Disorders
Spinal Cord Diseases
Vitamin B 12 Deficiency
English
We report two patients with subjectively progressive sensory symptoms and gait disturbance due to cobalamin deficiency, but only slight or absent abnormalities on neurological examination. In both patients, spinal MRI provided evidence for a myelopathic origin of the symptoms, disclosing characteristic T(2) hyperintense signal alterations confined to the posterior columns of the cervical and thoracic spinal cord. The patients illustrate the early clinical presentation of subacute combined degeneration (SCD) with a sensory neuropathy starting with acroparesthesia and Lhermitte's sign. Furthermore, the diagnostic value of spinal MRI for early diagnosis of SCD with characteristic findings is highlighted.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1159/000069087
- PMID 12646757
- Persistent URL
- https://sonar.ch/global/documents/192140
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