Lesions with unclear malignant potential (B3) after minimally invasive breast biopsy: evaluation of vacuum biopsies performed in Switzerland and recommended further management.
- Saladin C Institute of Radiology, Kantonsspital Baden AG, Baden, Switzerland camilla.saladin@bluewin.ch.
- Haueisen H Institute of Radiology, Kantonsspital Aarau AG, Aarau, Switzerland.
- Kampmann G Centro di Radiologia Luganese, Lugano, Switzerland.
- Oehlschlegel C Institute of Pathology, Kantonsspital St. Gallen, St. Gallen, Switzerland.
- Seifert B Division of Biostatistics, Institute for Social and Preventive Medicine, University of Zurich, Zürich, Switzerland.
- Rageth L Adjumed Services AG, Zurich, Switzerland.
- Rageth C Brustzentrum, Zurich, Switzerland.
- Stadlmann S Institute of Pathology, Kantonsspital Baden AG, Baden, Switzerland.
- Kubik-Huch RA Institute of Radiology, Kantonsspital Baden AG, Baden, Switzerland.
- 2015-11-11
Published in:
- Acta radiologica (Stockholm, Sweden : 1987). - 2016
B3 lesion
Breast cancer
ductal carcinoma in situ (DCIS)
invasive carcinoma
uncertain malignant potential
vacuum-assisted breast biopsy
Breast Neoplasms
Female
Humans
Image-Guided Biopsy
Magnetic Resonance Imaging, Interventional
Stereotaxic Techniques
Switzerland
Ultrasonography, Interventional
Vacuum
English
BACKGROUND
Histopathological B3 lesions after minimal invasive breast biopsy (VABB) are a particular challenge for the clinician, as there are currently no binding recommendations regarding the subsequent procedure.
PURPOSE
To analyze all B3 lesions, diagnosed at VABB and captured in the national central Swiss MIBB database and to provide a data basis for further management in this subgroup of patients.
MATERIAL AND METHODS
All 9,153 stereotactically, sonographically, or magnetic resonance imaging (MRI)-guided vacuum-assisted breast biopsies, performed in Switzerland between 2009 and 2011, captured in a central database, were evaluated. The rate of B3 lesions and the definitive pathological findings in patients who underwent surgical resection were analyzed.
RESULTS
The B3 rate was 17.0% (1532 of 9000 biopsies with B classification). Among the 521 lesions with a definitive postoperative diagnosis, the malignancy rate (invasive carcinoma or DCIS) was 21.5%. In patients with atypical ductal hyperplasia, papillary lesions, flat epithelial atypia, lobular neoplasia, and radial scar diagnosed by VABB, the malignancy rates were 25.9%, 3.1%, 18.3%, 26.4%, and 11.1%, respectively.
CONCLUSION
B3 lesions, comprising 17%, of all analyzed biopsies, were common and the proportion of malignancies in those lesions undergoing subsequent surgical excision was high (21.5%).
Histopathological B3 lesions after minimal invasive breast biopsy (VABB) are a particular challenge for the clinician, as there are currently no binding recommendations regarding the subsequent procedure.
PURPOSE
To analyze all B3 lesions, diagnosed at VABB and captured in the national central Swiss MIBB database and to provide a data basis for further management in this subgroup of patients.
MATERIAL AND METHODS
All 9,153 stereotactically, sonographically, or magnetic resonance imaging (MRI)-guided vacuum-assisted breast biopsies, performed in Switzerland between 2009 and 2011, captured in a central database, were evaluated. The rate of B3 lesions and the definitive pathological findings in patients who underwent surgical resection were analyzed.
RESULTS
The B3 rate was 17.0% (1532 of 9000 biopsies with B classification). Among the 521 lesions with a definitive postoperative diagnosis, the malignancy rate (invasive carcinoma or DCIS) was 21.5%. In patients with atypical ductal hyperplasia, papillary lesions, flat epithelial atypia, lobular neoplasia, and radial scar diagnosed by VABB, the malignancy rates were 25.9%, 3.1%, 18.3%, 26.4%, and 11.1%, respectively.
CONCLUSION
B3 lesions, comprising 17%, of all analyzed biopsies, were common and the proportion of malignancies in those lesions undergoing subsequent surgical excision was high (21.5%).
- Language
-
- English
- Open access status
- hybrid
- Identifiers
-
- DOI 10.1177/0284185115610931
- PMID 26552694
- Persistent URL
- https://sonar.ch/global/documents/193328
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