Follicular regulatory T cell in atherosclerosis.
- Baptista D Division of Cardiology, Foundation for Medical Researches, Department of Medicine Specialties, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
- Mach F Division of Cardiology, Foundation for Medical Researches, Department of Medicine Specialties, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
- Brandt KJ Division of Cardiology, Foundation for Medical Researches, Department of Medicine Specialties, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
- 2018-08-23
Published in:
- Journal of leukocyte biology. - 2018
Atherosclerosis
B cell
Follicular T cell
Regulatory B cells
Animals
Atherosclerosis
Humans
T-Lymphocytes, Regulatory
English
Atherosclerosis is a chronic inflammatory disease involving the infiltration of immune cells, such as monocytes/macrophages, neutrophils, T cells, and B cells, into the inner layer of vessel walls. T and B cell functions in the process of atherogenesis, as well as their mutual regulation, have been investigated but several aspects remain to be clarified. In the present review, we give a brief overview of the functions of follicular regulatory T cell (Tfr) on follicular T (Tfh) and B cell regulation related to atherosclerosis pathogenesis, including their influence on lymphangiogenesis and lipoprotein metabolism. We will also discuss their potential therapeutics properties in the resolution of established atherosclerotic lesions.
- Language
-
- English
- Open access status
- hybrid
- Identifiers
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- DOI 10.1002/JLB.MR1117-469R
- PMID 30134501
- Persistent URL
- https://sonar.ch/global/documents/194501
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