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Generation-dependent molecular recognition controls self-assembly in supramolecular dendron-virus complexes.
Journal article

Generation-dependent molecular recognition controls self-assembly in supramolecular dendron-virus complexes.

  • Doni G University of Applied Sciences of Southern Switzerland (SUPSI)-Mathematical and Physical Sciences Research Unit (SMF), Manno, Switzerland.
  • Kostiainen MA
  • Danani A
  • Pavan GM
  • 2010-12-22
Published in:
  • Nano letters. - 2011
Computer Simulation
Models, Biological
Models, Chemical
Models, Molecular
Virion
Virus Assembly
English In this work molecular dynamics simulation identifies a clear link between the dendron-virus multivalent molecular recognition and the nature of the consequent self-assembly. Data demonstrate how a weak hydrophobic association is transformed in an electrostatic self-assembly, orders of magnitude stronger, depending on the dendron generation used to assemble the viruses. This opens a new frontier in the engineering of hierarchical self-assemblies, potentially enabling the control of the supramolecular properties by acting at the single-molecule level.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/19612
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