Quantifying atherogenic lipoproteins for lipid-lowering strategies: consensus-based recommendations from EAS and EFLM.
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Langlois MR
Department of Laboratory Medicine, AZ St-Jan, Ruddershove 10, 8000 Brugge, Belgium.
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Nordestgaard BG
Herlev and Gentofte Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark.
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Langsted A
Herlev and Gentofte Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark.
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Chapman MJ
National Institute for Health and Medical Research (INSERM), Paris, France.
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Aakre KM
Hormone Laboratory, Haukeland University Hospital, Bergen, Norway.
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Baum H
Institute for Laboratory Medicine, Mikrobiologie und Blutdepot, Regionale Kliniken Holding RKH GmbH, Ludwigsburg, Germany.
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Borén J
Institute of Medicine, Sahlgrenska Academy at Göteborg University, Gothenburg, Sweden.
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Bruckert E
Department of Endocrinology and Prevention of Cardiovascular Disease, Pitié-Salpetriere University Hospital, Paris, France.
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Catapano A
Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy.
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Cobbaert C
Department of Clinical Chemistry and Laboratory Medicine, Leiden University Medical Center, Leiden, The Netherlands.
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Collinson P
Department of Clinical Blood Sciences, St George's University Hospitals NHS Foundation Trust and St George's University of London, London, UK.
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Descamps OS
Department of Internal Medicine, Centres Hospitaliers Jolimont, Haine-Saint-Paul, Belgium.
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Duff CJ
Department of Clinical Biochemistry, University Hospitals of North Midlands NHS Trust, Stoke-on-Trent, UK.
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von Eckardstein A
Institute for Clinical Chemistry, University Hospital Zurich, Zurich, Switzerland.
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Hammerer-Lercher A
Kantonspital Aarau AG, Institute for Laboratory Medicine, Aarau, Switzerland.
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Kamstrup PR
Herlev and Gentofte Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark.
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Kolovou G
Cardiology Department, Onassis Cardiac Surgery Center, Athens, Greece.
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Kronenberg F
Department of Medical Genetics, Molecular and Clinical Pharmacology, Division of Genetic Epidemiology, Medical University of Innsbruck, Innsbruck, Austria.
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Mora S
Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
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Pulkki K
Department of Clinical Chemistry, University of Turku and Turku University Hospital, Turku, Finland.
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Remaley AT
Lipoprotein Metabolism Section, Cardiovascular-Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
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Rifai N
Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
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Ros E
Lipid Clinic, Department of Endocrinology and Nutrition, Institut d'Investigacions Biomèdiques August Pi Sunyer, Hospital Clínic, Barcelona, Spain.
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Stankovic S
Center for Medical Biochemistry, Clinical Center of Serbia, Belgrade, Serbia.
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Stavljenic-Rukavina A
Libertas International University, Zagreb, Croatia.
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Sypniewska G
Department of Laboratory Medicine, Collegium Medicum, NC University, Bydgoszcz, Poland.
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Watts GF
Lipid Disorders Clinic, Department of Cardiology, Royal Perth Hospital, University of Western Australia, Perth, Australia.
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Wiklund O
Institute of Medicine, Sahlgrenska Academy at Göteborg University, Gothenburg, Sweden.
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Laitinen P
Department of Clinical Chemistry, HUSLAB, Helsinki University Hospital, Helsinki, Finland.
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Published in:
- Clinical chemistry and laboratory medicine. - 2020
English
The joint consensus panel of the European Atherosclerosis Society (EAS) and the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) recently addressed present and future challenges in the laboratory diagnostics of atherogenic lipoproteins. Total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDLC), LDL cholesterol (LDLC), and calculated non-HDLC (=total - HDLC) constitute the primary lipid panel for estimating risk of atherosclerotic cardiovascular disease (ASCVD) and can be measured in the nonfasting state. LDLC is the primary target of lipid-lowering therapies. For on-treatment follow-up, LDLC shall be measured or calculated by the same method to attenuate errors in treatment decisions due to marked between-method variations. Lipoprotein(a) [Lp(a)]-cholesterol is part of measured or calculated LDLC and should be estimated at least once in all patients at risk of ASCVD, especially in those whose LDLC declines poorly upon statin treatment. Residual risk of ASCVD even under optimal LDL-lowering treatment should be also assessed by non-HDLC or apolipoprotein B (apoB), especially in patients with mild-to-moderate hypertriglyceridemia (2-10 mmol/L). Non-HDLC includes the assessment of remnant lipoprotein cholesterol and shall be reported in all standard lipid panels. Additional apoB measurement can detect elevated LDL particle (LDLP) numbers often unidentified on the basis of LDLC alone. Reference intervals of lipids, lipoproteins, and apolipoproteins are reported for European men and women aged 20-100 years. However, laboratories shall flag abnormal lipid values with reference to therapeutic decision thresholds.
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bronze
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https://sonar.ch/global/documents/197285
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