A lncRNA to repair DNA.
- Lukas J NNF Center for Protein Research, University of Copenhagen, Copenhagen, Denmark.
- Altmeyer M IVBMB, University of Zurich, Zurich, Switzerland.
- 2015-10-01
Published in:
- EMBO reports. - 2015
English
Long non-coding RNAs (lncRNAs) have emerged as regulators of various biological processes, but to which extent lncRNAs play a role in genome integrity maintenance is not well understood. In this issue of EMBO Reports, Sharma et al [1] identify the DNA damage-induced lncRNA DDSR1 as an integral player of the DNA damage response (DDR). DDSR1 has both an early role by modulating repair pathway choices, and a later function when it regulates gene expression. Sharma et al [1] thus uncover a dual role for a hitherto uncharacterized lncRNA during the cellular response to DNA damage.
- Language
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- English
- Open access status
- green
- Identifiers
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- DOI 10.15252/embr.201541309
- PMID 26420434
- Persistent URL
- https://sonar.ch/global/documents/197449
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