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Axial differences in endocytosis along the kidney proximal tubule.
Journal article

Axial differences in endocytosis along the kidney proximal tubule.

  • Polesel M Institute of Anatomy, University of Zurich, Zurich, Switzerland.
  • Hall AM Institute of Anatomy, University of Zurich, Zurich, Switzerland.
  • 2019-10-29
Published in:
  • American journal of physiology. Renal physiology. - 2019
endocytosis
intravital multiphoton microscopy
kidney proximal tubule
proteinuria
Animals
Endocytosis
Humans
Kidney Tubules, Proximal
English The proximal tubule (PT) reabsorbs filtered proteins via receptor-mediated endocytosis to prevent energetically inefficient wasting in the urine. Recent intravital imaging studies have suggested that protein reabsorption occurs in early (S1) segments, which have a very high capacity. In contrast, uptake of fluid phase substrates also occurs in distal (S2) segments. In this article, we will review these findings and their implications for understanding integrated proximal tubular function, patterns of damage caused by endocytosed toxins, and the origins of proteinuria. We will also discuss whether compensatory downstream increases in protein uptake might occur in disease states, and the environmental factors that could drive these changes.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/197585
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