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Trace-Level Persistent Organic Pollutant Analysis with Gas-Chromatography Orbitrap Mass Spectrometry-Enhanced Performance by Complementary Acquisition and Processing of Time-Domain Data.
Journal article

Trace-Level Persistent Organic Pollutant Analysis with Gas-Chromatography Orbitrap Mass Spectrometry-Enhanced Performance by Complementary Acquisition and Processing of Time-Domain Data.

  • Nagornov KO Spectroswiss , EPFL Innovation Park, Building I, 1015 Lausanne , Switzerland.
  • Zennegg M Swiss Federal Laboratories for Materials Science and Technology (Empa) , Überlandstrasse 129 , 8600 Dübendorf , Switzerland.
  • Kozhinov AN Spectroswiss , EPFL Innovation Park, Building I, 1015 Lausanne , Switzerland.
  • Tsybin YO Spectroswiss , EPFL Innovation Park, Building I, 1015 Lausanne , Switzerland.
  • Bleiner D Swiss Federal Laboratories for Materials Science and Technology (Empa) , Überlandstrasse 129 , 8600 Dübendorf , Switzerland.
  • 2020-02-08
Published in:
  • Journal of the American Society for Mass Spectrometry. - 2020
Fourier transform
Orbitrap
organic pollutants
relative quantitation
English The range of commercial techniques for high-resolution gas-chromatography-mass spectrometry (GC-MS) has been recently extended with the introduction of GC Orbitrap Fourier transform mass spectrometry (FTMS). We report on progress with quantitation performance in the analysis of persistent organic pollutants (POP), by averaging of time-domain signals (transients), from a number of GC-FTMS experiment replicates. Compared to a standard GC-FTMS measurement (a single GC-FTMS experiment replicate, mass spectra representation in reduced profile mode), for the 10 GC-FTMS technical replicates of ultratrace POP analysis, sensitivity improvement of up to 1 order of magnitude is demonstrated. The accumulation method was implemented with an external high-performance data acquisition system and dedicated data processing software to acquire the time-domain data for each GC-FTMS replicate and to average the acquired GC-FTMS data sets. Concomitantly, the increased flexibility in ion signal detection allowed the attainment of ultrahigh-mass resolution (UHR), approaching R = 700 000 at m/z = 200.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/197684
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