Journal article
Molecular Physiology of Bile Acid Signaling in Health, Disease and Aging.
- Perino A SV-IBI, EPFL, Switzerland.
- Demagny H SV-IBI, EPFL, Switzerland.
- Velazquez-Villegas LA Instituto Nacional de Ciencias Médicas y Nutrición, S.Z.
- Schoonjans K Institute of Bioengineering, Laboratory of Integrative Systems Physiology, EPFL, Switzerland.
- 2020-08-14
Published in:
- Physiological reviews. - 2020
English
Over the last two decades, bile acids (BAs) have become established as important signaling molecules that enable fine-tuned inter-tissue communication from the liver, their site of production, over the intestine, where they are modified by the gut microbiota, to virtually any organ, where they exert their pleiotropic physiological effects. The chemical variety of BAs, to a large extent determined by the gut microbiome, also allows for a complex fine-tuning of adaptive responses in our body. This review provides an overview of the mechanisms by which BA receptors coordinate several aspects of physiology and highlights new therapeutic strategies for diseases underlying pathological BA signaling.
- Language
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- English
- Open access status
- closed
- Identifiers
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- DOI 10.1152/physrev.00049.2019
- PMID 32790577
- Persistent URL
- https://sonar.ch/global/documents/197731
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