The protein import receptor of mitochondria.

Lithgow T; Glick BS; Schatz G

doi:10.1016/s0968-0004(00)88972-0

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Journal article

The protein import receptor of mitochondria.

Lithgow T Biozentrum, University of Basel, Switzerland.
Glick BS
Schatz G

1995-03-01

Published in:

Trends in biochemical sciences. - 1995

Receptors, Cytoplasmic and Nuclear

English Protein import into the mitochondria of Saccharomyces cerevisiae depends on two receptor subcomplexes composed of integral outer-membrane proteins. One subcomplex is the MAS37-MAS70 heterodimer, which preferentially recognizes the mature regions of precursor proteins associated with ATP-dependent cytosolic chaperones. The other subcomplex contains the acidic proteins MAS20 and MAS22, which recognize the positively charged targeting sequences of a wide variety of mitochondrial precursors. We propose that the two subcomplexes can act together as a single, multifunctional receptor that binds simultaneously to different regions of a precursor molecule.

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