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Zebrafish Radar: a new member of the TGF-beta superfamily defines dorsal regions of the neural plate and the embryonic retina.
Journal article

Zebrafish Radar: a new member of the TGF-beta superfamily defines dorsal regions of the neural plate and the embryonic retina.

  • 1995-02-01
Published in:
  • Mechanisms of development. - 1995
Amino Acid Sequence
Animals
Base Sequence
Cloning, Molecular
Conserved Sequence
Molecular Sequence Data
Neural Crest
Retina
Sequence Alignment
Transforming Growth Factor beta
Zebrafish
English Proper development of metazoan embryos requires cell to cell communications. In many instances, these communications involve diffusible molecules, particularly members of the Transforming Growth Factor beta superfamily. In an effort to identify new members of this superfamily involved in the control of early zebrafish embryogenesis, we have isolated a gene, Radar, which appears to be conserved throughout vertebrate evolution and defines a new subfamily within the superfamily. Its pattern of expression suggests that Radar plays a role in the dorso-ventral polarity of the neural plate, blood islands formation, blood cells differentiation, the establishment of retinal dorso-ventral polarity and/or proper axonal retinotectal projections. Radar expression in ntl homozygous mutants indicates that notochord and hypochord development are intimately linked.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/198154
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