Journal article
Amygdala inhibitory circuits and the control of fear memory.
- Ehrlich I Friedrich Miescher Institute for Biomedical Research, 4058 Basel, Switzerland.
- Humeau Y
- Grenier F
- Ciocchi S
- Herry C
- Lüthi A
- 2009-06-27
Published in:
- Neuron. - 2009
Amygdala
Animals
Avoidance Learning
Conditioning, Classical
Extinction, Psychological
Fear
Humans
Memory
Nerve Net
Neural Inhibition
English
Classical fear conditioning is a powerful behavioral paradigm that is widely used to study the neuronal substrates of learning and memory. Previous studies have clearly identified the amygdala as a key brain structure for acquisition and storage of fear memory traces. Whereas the majority of this work has focused on principal cells and glutamatergic transmission and its plasticity, recent studies have started to shed light on the intricate roles of local inhibitory circuits. Here, we review current understanding and emerging concepts of how local inhibitory circuits in the amygdala control the acquisition, expression, and extinction of conditioned fear at different levels.
- Language
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- English
- Open access status
- closed
- Identifiers
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- DOI 10.1016/j.neuron.2009.05.026
- PMID 19555645
- Persistent URL
- https://sonar.ch/global/documents/198781
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