Journal article
ESCRT-III polymers in membrane neck constriction.
- Guizetti J Institute of Biochemistry, Swiss Federal Institute of Technology Zurich (ETHZ), Schafmattstr. 18, CH-8093 Zurich, Switzerland.
- Gerlich DW
- 2012-01-14
Published in:
- Trends in cell biology. - 2012
Animals
Cell Membrane
Cytoplasm
Endosomal Sorting Complexes Required for Transport
Humans
Protein Multimerization
Protein Subunits
English
The endosomal sorting complex required for transport (ESCRT)-III machinery contributes to membrane deformation and scission in cytokinesis, intraluminal vesicle formation, autophagy and virus budding. Recombinant ESCRT-III subunits polymerize in vitro into filaments, tubes, sheets or rings, and ESCRT-III-dependent filaments have been observed in cells at virus bud necks and at the cytokinetic abscission site. These observations have inspired speculation about how ESCRT-III could mediate constriction and fission of membrane necks. Based on the polymer structures observed in vitro and in vivo, we discuss models for ESCRT-III function and outline how emerging technologies could be used to test these models.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1016/j.tcb.2011.11.007
- PMID 22240455
- Persistent URL
- https://sonar.ch/global/documents/199259
Statistics
Document views: 35
File downloads: