Journal article
Resonance-enhanced microfluidic impedance cytometer for detection of single bacteria.
- Haandbæk N ETH Zurich, Dept. of Biosystems Science and Engineering, Mattenstrasse 26, Basel, CH-4058, Switzerland. niels.haandbaek@bsse.ethz.ch.
- With O
- Bürgel SC
- Heer F
- Hierlemann A
- 2014-07-02
Published in:
- Lab on a chip. - 2014
English
This paper reports on a novel impedance-based cytometer, which can detect and characterize sub-micrometer particles and cells passing through a microfluidic channel. The cytometer incorporates a resonator, which is constructed by means of a discrete inductor in series with the measurement electrodes in the microfluidic channel. The use of a resonator increases the sensitivity of the system in comparison to state-of-the-art devices. We demonstrate the functionality and sensitivity of the cytometer by discriminating E. coli and B. subtilis from beads of similar sizes by means of the resonance-enhanced phase shift of the current through the microfluidic channel. The phase shift can be correlated to size and dielectric properties of the measured objects.
- Language
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- English
- Open access status
- closed
- Identifiers
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- DOI 10.1039/c4lc00576g
- PMID 24984254
- Persistent URL
- https://sonar.ch/global/documents/199415
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